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The role of the Metzincin Superfamily in prostate cancer progression: a systematic-like review

Binder, Marley J and Ward, Alister C 2021, The role of the Metzincin Superfamily in prostate cancer progression: a systematic-like review, International journal of molecular sciences, vol. 22, no. 7, pp. 1-31, doi: 10.3390/ijms22073608.

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Title The role of the Metzincin Superfamily in prostate cancer progression: a systematic-like review
Author(s) Binder, Marley J
Ward, Alister CORCID iD for Ward, Alister C orcid.org/0000-0001-7945-7975
Journal name International journal of molecular sciences
Volume number 22
Issue number 7
Article ID 3608
Start page 1
End page 31
Total pages 31
Publisher MDPI AG
Place of publication Basel, Switzerland
Publication date 2021-03-30
ISSN 1422-0067
1422-0067
Keyword(s) A Disintegrin and Metalloproteinase
A Disintegrin and Metalloproteinase with Thrombospondin Motifs
Matrix Metalloproteinase
metzincin
prostate cancer
Tissue Inhibitor of Metalloproteinases
Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemistry & Molecular Biology
Chemistry, Multidisciplinary
Chemistry
Summary Prostate cancer remains a leading cause of cancer-related morbidity in men. Potentially important regulators of prostate cancer progression are members of the metzincin superfamily of proteases, principally through their regulation of the extracellular matrix. It is therefore timely to review the role of the metzincin superfamily in prostate cancer and its progression to better understand their involvement in this disease. A systematic-like search strategy was conducted. Articles that investigated the roles of members of the metzincin superfamily and their key regulators in prostate cancer were included. The extracted articles were synthesized and data presented in tabular and narrative forms. Two hundred and five studies met the inclusion criteria. Of these, 138 investigated the role of the Matrix Metalloproteinase (MMP) subgroup, 34 the Membrane-Tethered Matrix Metalloproteinase (MT-MMP) subgroup, 22 the A Disintegrin and Metalloproteinase (ADAM) subgroup, 8 the A Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) subgroup and 53 the Tissue Inhibitor of Metalloproteinases (TIMP) family of regulators, noting that several studies investigated multiple family members. There was clear evidence that specific members of the metzincin superfamily are involved in prostate cancer progression, which can be either in a positive or negative manner. However, further understanding of their mechanisms of action and how they may be used as prognostic indicators or molecular targets is required.
Language eng
DOI 10.3390/ijms22073608
Indigenous content off
Field of Research 0399 Other Chemical Sciences
0604 Genetics
0699 Other Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30149949

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.