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C-reactive protein predicts complications in community-associated S. aureus bacteraemia: a cohort study

Botheras, Carly, Bowe, Steven, Cowan, Raquel and Athan, Eugene 2021, C-reactive protein predicts complications in community-associated S. aureus bacteraemia: a cohort study, BMC infectious diseases, vol. 21, no. 1, pp. 1-10, doi: 10.1186/s12879-021-05962-7.

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Title C-reactive protein predicts complications in community-associated S. aureus bacteraemia: a cohort study
Author(s) Botheras, Carly
Bowe, StevenORCID iD for Bowe, Steven orcid.org/0000-0003-3813-842X
Cowan, Raquel
Athan, EugeneORCID iD for Athan, Eugene orcid.org/0000-0001-9838-6471
Journal name BMC infectious diseases
Volume number 21
Issue number 1
Article ID 312
Start page 1
End page 10
Total pages 10
Publisher BioMed Central
Place of publication London, Eng.
Publication date 2021
ISSN 1471-2334
1471-2334
Keyword(s) S. aureus bacteraemia
Complications
Epidemiology
C-reactive protein
Infectious Diseases
Life Sciences & Biomedicine
Science & Technology
S
aureus bacteraemia
Summary Background Staphylococcus aureus (S. aureus) bacteraemia is increasingly acquired from community settings and is associated with a mortality rate of up to 40% following complications. Identifying risk factors for complicated S. aureus bacteraemia would aid clinicians in targeting patients that benefit from expedited investigations and escalated care. Methods In this prospective observational cohort study, we aimed to identify risk factors associated with a complicated infection in community-onset S. aureus bacteraemia. Potential risk factors were collected from electronic medical records and included: - patient demographics, symptomology, portal of entry, and laboratory results. Results We identified several potential risk factors using univariate analysis. In a multiple logistic regression model, age, haemodialysis, and entry point from a diabetic foot ulcer were all significantly protective against complications. Conversely, an unknown entry point of infection, an entry point from an indwelling medical device, and a C-reactive protein concentration of over 161 mg/L on the day of admission were all significantly associated with complications. Conclusions We conclude that several factors are associated with complications including already conducted laboratory investigations and portal of entry of infection. These factors could aid the triage of at-risk patients for complications of S. aureus bacteraemia.
Language eng
DOI 10.1186/s12879-021-05962-7
Indigenous content off
Field of Research 0605 Microbiology
1103 Clinical Sciences
1108 Medical Microbiology
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30149958

Document type: Journal Article
Collections: Faculty of Health
PVC's Office - Health
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.