Social Cognitive Dysfunction following Pediatric Arterial Ischemic Stroke: Evidence from a Prospective Cohort Study

Ryan, Nicholas, Greenham, M, Gordon, AL, Ditchfield, M, Coleman, L, Cooper, A, Crowe, L, Hunt, RW, Monagle, P, MacKay, MT and Anderson, V 2021, Social Cognitive Dysfunction following Pediatric Arterial Ischemic Stroke: Evidence from a Prospective Cohort Study, Stroke, vol. 52, no. 5, pp. 1609-1617, doi: 10.1161/STROKEAHA.120.032955.

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Title Social Cognitive Dysfunction following Pediatric Arterial Ischemic Stroke: Evidence from a Prospective Cohort Study
Author(s) Ryan, NicholasORCID iD for Ryan, Nicholas
Greenham, M
Gordon, AL
Ditchfield, M
Coleman, L
Cooper, A
Crowe, L
Hunt, RW
Monagle, P
MacKay, MT
Anderson, V
Journal name Stroke
Volume number 52
Issue number 5
Start page 1609
End page 1617
Total pages 9
Publisher Lippincott Williams & Wilkins
Place of publication [Philadelphia, PA]
Publication date 2021-05
ISSN 0039-2499
Keyword(s) adolescent
Cardiovascular System & Cardiology
Clinical Neurology
Life Sciences & Biomedicine
Neurosciences & Neurology
Peripheral Vascular Disease
Science & Technology
social cognition
theory of mind
Summary Background and Purpose: Childhood and adolescence coincide with rapid maturation of distributed brain networks supporting social cognition; however, little is known about the impact of early ischemic brain insult on the acquisition of these skills. This study aimed to examine the influence of arterial ischemic stroke (AIS) on facial emotion recognition and theory of mind (ToM) abilities of children and adolescents initially recruited to a single-center, prospective longitudinal study of recovery following AIS. Methods: The study involved 67 participants, including 30 children with AIS (mean time since stroke=5 years) and 37 age-matched typically developing controls who were assessed on measures of cognitive ToM, facial emotion recognition, and affective ToM. Acute clinical magnetic resonance imaging, including diffusion-weighted imaging sequences, were used to evaluate prospective structure-function relationships between acute lesion characteristics (size, location, and arterial territories affected) and long-term social cognitive abilities. Results: Relative to age-matched typically developing controls, children with AIS showed significantly worse performance on measures of basic facial emotion processing, cognitive ToM, and affective ToM. In univariate models, poorer ToM was associated with larger infarcts, combined cortical-subcortical pathology, and involvement of multiple arterial territories. In multivariate analyses, larger lesions and multiterritory infants were predictive of ToM processing but not facial emotion recognition. Poorer cognitive ToM predicted less frequent prosocial behavior and increased peer problems. Conclusions: Social cognitive skills appear vulnerable to disruption from early ischemic brain insult. In the first study to examine social cognition in a prospective cohort of children with AIS, our findings suggest that acute magnetic resonance imaging-based lesion characteristics may have predictive value for long-term social cognitive outcomes and may assist to identify children at elevated risk for social cognitive dysfunction.
Language eng
DOI 10.1161/STROKEAHA.120.032955
Indigenous content off
Field of Research 1102 Cardiorespiratory Medicine and Haematology
1103 Clinical Sciences
1109 Neurosciences
HERDC Research category C1 Refereed article in a scholarly journal
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Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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