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Cortical plasticity and interneuron recruitment in adolescents born to women with gestational diabetes mellitus

Van Dam, Jago M, Goldsworthy, Mitchell R, Hague, William M, Coat, Suzette and Pitcher, Julia B 2021, Cortical plasticity and interneuron recruitment in adolescents born to women with gestational diabetes mellitus, Brain sciences, vol. 11, no. 3, pp. 1-12, doi: 10.3390/brainsci11030388.

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Title Cortical plasticity and interneuron recruitment in adolescents born to women with gestational diabetes mellitus
Author(s) Van Dam, Jago M
Goldsworthy, Mitchell R
Hague, William M
Coat, Suzette
Pitcher, Julia BORCID iD for Pitcher, Julia B orcid.org/0000-0002-9648-7540
Journal name Brain sciences
Volume number 11
Issue number 3
Article ID 388
Start page 1
End page 12
Total pages 12
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2021-03
ISSN 2076-3425
2076-3425
Keyword(s) gestational diabetes
transcranial magnetic stimulation
cortisol
neuroplasticity
I-waves
neurodevelopment
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
Science & Technology
Summary Exposure to gestational diabetes mellitus (GDM) in utero is associated with a range of adverse cognitive and neurological outcomes. Previously, we reported altered neuroplastic responses to continuous theta burst stimulation (cTBS) in GDM-exposed adolescents. Recent research suggests that the relative excitability of complex oligosynaptic circuits (late I-wave circuits) can predict these responses. We aimed to determine if altered I-wave recruitment was associated with neuroplastic responses in adolescents born to women with GDM. A total of 20 GDM-exposed adolescents and 10 controls (aged 13.1 ± 1.0 years) participated. cTBS was used to induce neuroplasticity. I-wave recruitment was assessed by comparing motor-evoked potential latencies using different TMS coil directions. Recruitment of late I-waves was associated with stronger LTD-like neuroplastic responses to cTBS (p = < 0.001, R2 = 0.36). There were no differences between groups in mean neuroplasticity (p = 0.37), I-wave recruitment (p = 0.87), or the association between these variables (p = 0.41). The relationship between I-wave recruitment and the response to cTBS previously observed in adults is also present in adolescents and does not appear to be altered significantly by in utero GDM exposure. Exposure to GDM does not appear to significantly impair LTD-like synaptic plasticity or interneuron recruitment.
Language eng
DOI 10.3390/brainsci11030388
Indigenous content off
Field of Research 1109 Neurosciences
1701 Psychology
1702 Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30149978

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.