Openly accessible

High maternal omega-3 supplementation dysregulates body weight and leptin in newborn male and female rats: implications for hypothalamic developmental programming

Xavier, Soniya, Gili, Jasmine, McGowan, Peter, Younesi, Simin, Wright, Paul FA, Walker, David W, Spencer, Sarah J and Sominsky, Luba 2021, High maternal omega-3 supplementation dysregulates body weight and leptin in newborn male and female rats: implications for hypothalamic developmental programming, Nutrients, vol. 13, no. 1, pp. 1-19, doi: 10.3390/nu13010089.

Attached Files
Name Description MIMEType Size Downloads

Title High maternal omega-3 supplementation dysregulates body weight and leptin in newborn male and female rats: implications for hypothalamic developmental programming
Author(s) Xavier, Soniya
Gili, Jasmine
McGowan, Peter
Younesi, Simin
Wright, Paul FA
Walker, David W
Spencer, Sarah J
Sominsky, Luba
Journal name Nutrients
Volume number 13
Issue number 1
Article ID 89
Start page 1
End page 19
Total pages 19
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2021-01
ISSN 2072-6643
2072-6643
Keyword(s) omega-3
pregnancy
development
leptin
hypothalamus
Life Sciences & Biomedicine
Nutrition & Dietetics
Science & Technology
Summary Maternal diet is critical for offspring development and long-term health. Here we investigated the effects of a poor maternal diet pre-conception and during pregnancy on metabolic outcomes and the developing hypothalamus in male and female offspring at birth. We hypothesised that offspring born to dams fed a diet high in fat and sugar (HFSD) peri-pregnancy will have disrupted metabolic outcomes. We also determined if these HFSD-related effects could be reversed by a shift to a healthier diet post-conception, in particular to a diet high in omega-3 polyunsaturated fatty acids (ω3 PUFAs), since ω3 PUFAs are considered essential for normal neurodevelopment. Unexpectedly, our data show that there are minimal negative effects of maternal HFSD on newborn pups. On the other hand, consumption of an ω3-replete diet during pregnancy altered several developmental parameters. As such, pups born to high-ω3-fed dams weighed less for their length, had reduced circulating leptin, and also displayed sex-specific disruption in the expression of hypothalamic neuropeptides. Collectively, our study shows that maternal intake of a diet rich in ω3 PUFAs during pregnancy may be detrimental for some metabolic developmental outcomes in the offspring. These data indicate the importance of a balanced dietary intake in pregnancy and highlight the need for further research into the impact of maternal ω3 intake on offspring development and long-term health.
Language eng
DOI 10.3390/nu13010089
Indigenous content off
Field of Research 0908 Food Sciences
1111 Nutrition and Dietetics
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30150200

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 12 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Tue, 20 Apr 2021, 11:11:12 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.