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Glial remodeling enhances short-term memory performance in Wistar rats

De Luca, Simone N, Soch, Alita, Sominsky, Luba, Nguyen, Thai-Xinh, Bosakhar, Abdulhameed and Spencer, Sarah J 2020, Glial remodeling enhances short-term memory performance in Wistar rats, Journal of neuroinflammation, vol. 17, no. 1, pp. 1-18, doi: 10.1186/s12974-020-1729-4.

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Title Glial remodeling enhances short-term memory performance in Wistar rats
Author(s) De Luca, Simone N
Soch, Alita
Sominsky, Luba
Nguyen, Thai-Xinh
Bosakhar, Abdulhameed
Spencer, Sarah J
Journal name Journal of neuroinflammation
Volume number 17
Issue number 1
Article ID 52
Start page 1
End page 18
Total pages 18
Publisher BioMed Central
Place of publication London, Eng.
Publication date 2020
ISSN 1742-2094
1742-2094
Keyword(s) Astrocytes
Cognition
Golgi
Immunology
Life Sciences & Biomedicine
Microglia
Neurosciences
Neurosciences & Neurology
Science & Technology
Transgenic rat
Summary Background Microglia play a key role in neuronal circuit and synaptic maturation in the developing brain. In the healthy adult, however, their role is less clear: microglial hyperactivation in adults can be detrimental to memory due to excessive synaptic pruning, yet learning and memory can also be impaired in the absence of these cells. In this study, we therefore aimed to determine how microglia contribute to short-term memory in healthy adults. Methods To this end, we developed a Cx3cr1-Dtr transgenic Wistar rat with a diphtheria toxin receptor (Dtr) gene inserted into the fractalkine receptor (Cx3cr1) promoter, expressed on microglia and monocytes. This model allows acute microglial and monocyte ablation upon application of diphtheria toxin, enabling us to directly assess microglia’s role in memory. Results Here, we show that short-term memory in the novel object and place recognition tasks is entirely unaffected by acute microglial ablation. However, when microglia repopulate the brain after depletion, learning and memory performance in these tasks is improved. This transitory memory enhancement is associated with an ameboid morphology in the newly repopulated microglial cells and increased astrocyte density that are linked with a higher density of mature hippocampal synaptic spines and differences in pre- and post-synaptic markers. Conclusions These data indicate that glia play a complex role in the healthy adult animal in supporting appropriate learning and memory and that subtle changes to the function of these cells may strategically enhance memory.
Language eng
DOI 10.1186/s12974-020-1729-4
Indigenous content off
Field of Research 1103 Clinical Sciences
1107 Immunology
1109 Neurosciences
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30150207

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.