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Chronic predator stress in female mice reduces primordial follicle numbers: implications for the role of ghrelin

Di Natale, M R, Soch, A, Ziko, I, De Luca, S N, Spencer, S J and Sominsky, Luba 2019, Chronic predator stress in female mice reduces primordial follicle numbers: implications for the role of ghrelin, Journal of endocrinology, vol. 241, no. 3, pp. 201-219, doi: 10.1530/JOE-19-0109.

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Title Chronic predator stress in female mice reduces primordial follicle numbers: implications for the role of ghrelin
Author(s) Di Natale, M R
Soch, A
Ziko, I
De Luca, S N
Spencer, S J
Sominsky, Luba
Journal name Journal of endocrinology
Volume number 241
Issue number 3
Start page 201
End page 219
Total pages 19
Publisher BioScientifica Ltd.
Place of publication Bristol, Eng.
Publication date 2019
ISSN 0022-0795
1479-6805
Keyword(s) acyl ghrelin
ANTI-MULLERIAN HORMONE
CORTICOTROPIN-RELEASING-FACTOR
Endocrinology & Metabolism
GHSR
GRANULOSA-CELLS
HORMONE SECRETAGOGUE RECEPTOR
HUMAN OVARIAN-FOLLICLES
INDUCED SUPPRESSION
Life Sciences & Biomedicine
LUTEINIZING-HORMONE
ovary
Science & Technology
SEX-DIFFERENCES
SOCIAL TRANSMISSION
STIMULATING-HORMONE
stress
Summary Chronic stress is a known suppressor of female reproductive function. However, attempts to isolate single causal links between stress and reproductive dysfunction have not yet been successful due to their multi-faceted aetiologies. The gut-derived hormone ghrelin regulates stress and reproductive function and may therefore be pivotal in the neuroendocrine integration of the hypothalamic–pituitary–adrenal (HPA) and –gonadal (HPG) axes. Here, we hypothesised that chronic stress disrupts ovarian follicle maturation and that this effect is mediated by a stress-induced increase in acyl ghrelin and activation of the growth hormone secretatogue receptor (GHSR). We gave C57BL/6J female mice 30 min daily chronic predator stress for 4 weeks, or no stress, and gave them daily GHSR antagonist (d-Lys3-GHRP-6) or saline. Exposure to chronic predator stress reduced circulating corticosterone, elevated acyl ghrelin levels and led to significantly depleted primordial follicle numbers. GHSR antagonism stress-dependently altered the expression of genes regulating ovarian responsiveness to gonadotropins and was able to attenuate the stress-induced depletion of primordial follicles. These findings suggest that chronic stress-induced elevations of acyl ghrelin may be detrimental for ovarian follicle maturation.
Language eng
DOI 10.1530/JOE-19-0109
Indigenous content off
Field of Research 0702 Animal Production
0707 Veterinary Sciences
1103 Clinical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30150224

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.