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Quantitative assessment of the lumbar intervertebral disc via T2 shows excellent long-term reliability

Belavy, Daniel L., Owen, Patrick J, Armbrecht, Gabriele, Bansmann, Martin, Zange, Jochen, Ling, Yuan, Pohle-Fröhlich, Regina and Felsenberg, Dieter 2021, Quantitative assessment of the lumbar intervertebral disc via T2 shows excellent long-term reliability, PLoS One, vol. 16, no. 4, pp. 1-13, doi: 10.1371/journal.pone.0249855.

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Title Quantitative assessment of the lumbar intervertebral disc via T2 shows excellent long-term reliability
Author(s) Belavy, Daniel L.
Owen, Patrick JORCID iD for Owen, Patrick J orcid.org/0000-0003-3924-9375
Armbrecht, Gabriele
Bansmann, Martin
Zange, Jochen
Ling, Yuan
Pohle-Fröhlich, Regina
Felsenberg, Dieter
Journal name PLoS One
Volume number 16
Issue number 4
Article ID e0249855
Start page 1
End page 13
Total pages 13
Publisher Public Library of Science
Place of publication San Francisco, Calif.
Publication date 2021-04
ISSN 1932-6203
1932-6203
Keyword(s) AGREEMENT
DEGENERATION
MRI
Multidisciplinary Sciences
RACEMIZATION
REPRODUCIBILITY
Science & Technology
Science & Technology - Other Topics
TURNOVER
WATER-CONTENT
Summary Methodologies for the quantitative assessment of the spine tissues, in particular the intervertebral disc (IVD), have not been well established in terms of long-term reliability. This is required for designing prospective studies. 1H water T2 in the IVD (“T2”) has attained wider use in assessment of the lumbar intervertebral discs via magnetic resonance imaging. The reliability of IVD T2 measurements are yet to be established. IVD T2 was assessed nine times at regular intervals over 368 days on six anatomical slices centred at the lumbar spine using a spin-echo multi-echo sequence in 12 men. To assess repeatability, intra-class correlation co-efficients (ICCs), standard error of the measurement, minimal detectable difference and co-efficients of variation (CVs) were calculated along with their 95% confidence intervals. Bland-Altman analysis was also performed. ICCs were above 0.93, with the exception of nuclear T2 at L5/S1, where the ICC was 0.88. CVs of the central-slice nucleus sub-region ranged from 4.3% (average of all levels) to 10.1% for L5/S1 and between 2.2% to 3.2% for whole IVD T2 (1.8% for the average of all levels). Averaging between vertebral levels improved reliability. Reliability of measurements was least at L5/S1. ICCs of degenerated IVDs were lower. Test-retest reliability was excellent for whole IVD and good to excellent for IVD subregions. The findings help to establish the long-term repeatability of lumbar IVD T2 for the implementation of prospective studies and determination of significant changes within individuals.
Language eng
DOI 10.1371/journal.pone.0249855
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30150241

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.