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The dietary inflammatory index and human health: an umbrella review of meta-analyses of observational studies

Marx, Wolfgang, Veronese, N, Kelly, J T, Smith, L, Hockey, Meghan, Collins, Sam, Trakman, G L, Hoare, Erin, Teasdale, S B, Wade, A, Lane, Melissa, Aslam, Hajara, Davis, Jessica A., O'Neil, Adrienne, Shivappa, N, Hebert, J R, Blekkenhorst, L C, Berk, Michael, Segasby, T and Jacka, Felice 2021, The dietary inflammatory index and human health: an umbrella review of meta-analyses of observational studies, Advances in nutrition, pp. 1-10, doi: 10.1093/advances/nmab037.

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Title The dietary inflammatory index and human health: an umbrella review of meta-analyses of observational studies
Author(s) Marx, WolfgangORCID iD for Marx, Wolfgang orcid.org/0000-0002-8556-8230
Veronese, N
Kelly, J T
Smith, L
Hockey, MeghanORCID iD for Hockey, Meghan orcid.org/0000-0003-2091-956X
Collins, Sam
Trakman, G L
Hoare, ErinORCID iD for Hoare, Erin orcid.org/0000-0001-6186-0221
Teasdale, S B
Wade, A
Lane, Melissa
Aslam, Hajara
Davis, Jessica A.
O'Neil, Adrienne
Shivappa, N
Hebert, J R
Blekkenhorst, L C
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Segasby, T
Jacka, FeliceORCID iD for Jacka, Felice orcid.org/0000-0002-9825-0328
Journal name Advances in nutrition
Start page 1
End page 10
Total pages 10
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2021
ISSN 2161-8313
2156-5376
Keyword(s) cancer
cardiovascular disease
diet
dietary inflammatory index
inflammation
medicine
mental disorders
non-communicable disorders
prevention
Summary ABSTRACT Numerous observational studies have investigated the role of the Dietary Inflammatory Index (DII®) in chronic disease risk. The aims of this umbrella review and integrated meta-analyses were to systematically synthesize the observational evidence reporting on the associations between the DII and health outcomes based on meta-analyses, and to assess the quality and strength of the evidence for each associated outcome. This umbrella review with integrated meta-analyses investigated the association between the DII and a range of health outcomes based on meta-analyses of observational data. A credibility assessment was conducted for each outcome using the following criteria: statistical heterogeneity, 95% prediction intervals, evidence for small-study effect and/or excess significance bias, as well as effect sizes and P values using calculated random effects meta-analyses. In total, 15 meta-analyses reporting on 38 chronic disease-related outcomes were included, incorporating a total population of 4,360,111 subjects. Outcomes (n = 38) were examined through various study designs including case-control (n = 8), cross-sectional (n = 5), prospective (n = 5), and combination (n = 20) study designs. Adherence to a pro-inflammatory dietary pattern had a significant positive association with 27 (71%) of the included health outcomes (P value < 0.05). Using the credibility assessment, Class I (Convincing) evidence was identified for myocardial infarction only, Class II (Highly suggestive) evidence was identified for increased risk of all-cause mortality, overall risk of incident cancer, and risk of incident site-specific cancers (colorectal, pancreatic, respiratory, and oral cancers) with increasing (more pro-inflammatory) DII score. Most outcomes (n = 31) presented Class III (Suggestive) or lower evidence (Weak or No association). Pro-inflammatory dietary patterns were nominally associated with an increased risk of many chronic disease outcomes. However, the strength of evidence for most outcomes was limited. Further prospective studies are required to improve the precision of the effect size.
Notes Advance Article
Language eng
DOI 10.1093/advances/nmab037
Indigenous content off
Field of Research 110999 Neurosciences not elsewhere classified
1111 Nutrition and Dietetics
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30150302

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.