Encapsulation of lipid-based formulations in porous carriers for controlled drug delivery

Tran, Ha Lien Phuong and Tran, TTD 2021, Encapsulation of lipid-based formulations in porous carriers for controlled drug delivery, Current Medicinal Chemistry, pp. 1-1, doi: 10.2174/0929867328666210420103841.

Title Encapsulation of lipid-based formulations in porous carriers for controlled drug delivery
Author(s) Tran, Ha Lien PhuongORCID iD for Tran, Ha Lien Phuong orcid.org/0000-0001-8463-7516
Tran, TTD
Journal name Current Medicinal Chemistry
Start page 1
End page 1
Total pages 1
Publisher Bentham Science Publishers
Place of publication Schiphol, The Netherlands
Publication date 2021-04-20
ISSN 0929-8673
Keyword(s) controlled drug release
Lipid-based formulation
poorly water-soluble drugs
porous carrier
technical methods.
technical methods.
Summary :Lipid-based formulations have recently been investigated as a promising approach to enhance the bioavailability of drugs, especially poorly water-soluble drugs. The encapsulation of lipid-based formulations in porous materials can result in a transformation of liquids or semisolid forms to solid dosage forms. Moreover, the specific structure of porous carriers could offer an enhanced ability to load and control active pharmaceutical ingredients. Although there have been prominent reports on lipid-based formulations and porous materials as promising technologies for controlled drug release, the overall methods of encapsulating lipid-based formulations need to be discussed for further formulation investigations. This review aims to present the key strategies used for producing porous carriers containing lipid-based formulations. We also discuss methods that enhance the encapsulation efficiency of loaded drugs within porous structures (instead of lipid-based formulations). Moreover, the critical factors that affect tablet formation are outlined. This overview of lipid-based formulations encapsulated within porous materials provides a summary of the technical methods used in the development of these formulations and their clinical translation.
Notes In Press
Language eng
DOI 10.2174/0929867328666210420103841
Indigenous content off
Field of Research 0304 Medicinal and Biomolecular Chemistry
0601 Biochemistry and Cell Biology
1115 Pharmacology and Pharmaceutical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30150360

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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