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Influence of childhood trauma on the treatment outcomes of pharmacological and/or psychological interventions for adolescents and adults with bipolar disorder: protocol for a systematic review and meta-analysis

Wrobel, Anna, Russell, Samantha E, Dean, Olivia M, Cotton, Sue, Berk, Michael and Turner, Alyna 2021, Influence of childhood trauma on the treatment outcomes of pharmacological and/or psychological interventions for adolescents and adults with bipolar disorder: protocol for a systematic review and meta-analysis, BMJ open, vol. 11, no. 4, pp. 1-8, doi: 10.1136/bmjopen-2020-044569.

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Title Influence of childhood trauma on the treatment outcomes of pharmacological and/or psychological interventions for adolescents and adults with bipolar disorder: protocol for a systematic review and meta-analysis
Author(s) Wrobel, Anna
Russell, Samantha E
Dean, Olivia MORCID iD for Dean, Olivia M orcid.org/0000-0002-2776-3935
Cotton, Sue
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Turner, AlynaORCID iD for Turner, Alyna orcid.org/0000-0001-7389-2546
Journal name BMJ open
Volume number 11
Issue number 4
Article ID e044569
Start page 1
End page 8
Total pages 8
Publisher BMJ Publishing Group
Place of publication London, Eng.
Publication date 2021-04
ISSN 2044-6055
Keyword(s) depression & mood disorders
mental health
psychiatry
Summary Despite available pharmacological and psychological treatments, remission rates for bipolar disorder remain relatively low. Current research implicates the experience of childhood trauma as a potential moderator of poor treatment outcomes among individuals with bipolar disorder. To date, the evidence reporting the influence of childhood trauma on the treatment outcomes of pharmacological and/or psychological interventions for adolescents and adults with bipolar disorder has not been systematically reviewed. MEDLINE Complete, Embase, PsycINFO and the Cochrane Central Register of Controlled Trials will be searched to identify randomised and nonrandomised studies of pharmacological and/or psychological interventions for bipolar disorder, which also assessed childhood trauma. To be eligible for inclusion, studies must have been conducted with adolescents or adults (≥10 years). Data will be screened and extracted by two independent reviewers. The methodological quality of the included studies will be assessed with the Cochrane Collaboration’s Risk of Bias tool and the Newcastle-Ottawa Scale. If deemed viable, a meta-analysis will be conducted using a random effects model. Heterogeneity of evidence will be estimated with the I² statistics. This systematic review will use only previously published data. Therefore, ethical approval is not required. The results will be written in concordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines, published in peer-reviewed journals and presented at relevant conferences. CRD42020201891.
Language eng
DOI 10.1136/bmjopen-2020-044569
Indigenous content off
Field of Research 110999 Neurosciences not elsewhere classified
1103 Clinical Sciences
1117 Public Health and Health Services
1199 Other Medical and Health Sciences
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30150696

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.