Longitudinal cognitive performance in individuals at ultrahigh risk for psychosis: a 10-year follow-up

Allott, K, Wood, S J, Yuen, H P, Yung, Alison R., Nelson, B, Brewer, W J, Spiliotacopoulos, D, Bruxner, A, Simmons, M, Broussard, C, Mallawaarachchi, S, Pantelis, C, McGorry, P D and Lin, A 2019, Longitudinal cognitive performance in individuals at ultrahigh risk for psychosis: a 10-year follow-up, Schizophrenia bulletin, vol. 45, no. 5, pp. 1101-1111, doi: 10.1093/schbul/sby143.

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Title Longitudinal cognitive performance in individuals at ultrahigh risk for psychosis: a 10-year follow-up
Author(s) Allott, K
Wood, S J
Yuen, H P
Yung, Alison R.
Nelson, B
Brewer, W J
Spiliotacopoulos, D
Bruxner, A
Simmons, M
Broussard, C
Mallawaarachchi, S
Pantelis, C
McGorry, P D
Lin, A
Journal name Schizophrenia bulletin
Volume number 45
Issue number 5
Start page 1101
End page 1111
Total pages 11
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2019-09
ISSN 0586-7614
1745-1701
Keyword(s) 1ST EPISODE
AT-RISK
clinical high risk
CLINICAL HIGH-RISK
cognition
EARLY ADULTHOOD
functioning
Life Sciences & Biomedicine
longitudinal
NEUROCOGNITION
POSTONSET PERIOD
prodrome
Psychiatry
psychosis
SCHIZOPHRENIA
Science & Technology
SHORT FORMS
SYMPTOMATIC REMISSION
ultrahigh risk
YOUNG-ADULTS
Summary It remains unclear whether the onset of psychosis is associated with deterioration in cognitive performance. The aim of this study was to examine the course of cognitive performance in an ultrahigh risk (UHR) cohort, and whether change in cognition is associated with transition to psychosis and change in functioning. Consecutive admissions to Personal Assessment and Crisis Evaluation (PACE) Clinic between May 1994 and July 2000 who had completed a comprehensive cognitive assessment at baseline and follow-up were eligible (N = 80). Follow-up ranged from 7.3 to 13.4 years (M = 10.4 years; SD = 1.5). In the whole sample, significant improvements were observed on the Similarities (P = .03), Information (P < .01), Digit Symbol Coding (P < .01), and Trail Making Test-B (P = .01) tasks, whereas performance on the Rey Auditory Verbal Learning Test (Trials 1–3) declined significantly (P < .01) over the follow-up period. Change in performance on cognitive measures was not significantly associated with transition status. Taking time to transition into account, those who transitioned after 1 year showed significant decline on Digit Symbol Coding, whereas those who did not transition improved on this measure (P = .01; effect size [ES] = 0.85). Small positive correlations were observed between improvements in functioning and improvements in performance on Digit Symbol Coding and Arithmetic (0.24, P = .03 and 0.28, P = .01, respectively). In summary, the onset of psychosis was not associated with deterioration in cognitive ability. However, specific findings suggest that immediate verbal learning and memory, and processing speed may be relevant domains for future risk models and early intervention research in UHR individuals.
Language eng
DOI 10.1093/schbul/sby143
Indigenous content off
Field of Research 11 Medical and Health Sciences
17 Psychology and Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30150794

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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