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Pituitary volume in psychosis

Pariante, CM, Vassilopoulou, K, Velakoulis, D, Phillips, L, Soulsby, B, Wood, SJ, Brewer, W, Smith, DJ, Dazzan, P, Yung, Alison, Zervas, IM, Christodoulou, GN, Murray, R, McGorry, PD and Pantelis, C 2004, Pituitary volume in psychosis, British Journal of Psychiatry, vol. 185, no. JULY, pp. 5-10, doi: 10.1192/bjp.185.1.5.


Title Pituitary volume in psychosis
Author(s) Pariante, CM
Vassilopoulou, K
Velakoulis, D
Phillips, L
Soulsby, B
Wood, SJ
Brewer, W
Smith, DJ
Dazzan, P
Yung, Alison
Zervas, IM
Christodoulou, GN
Murray, R
McGorry, PD
Pantelis, C
Journal name British Journal of Psychiatry
Volume number 185
Issue number JULY
Start page 5
End page 10
Total pages 6
Publisher CAMBRIDGE UNIV PRESS
Place of publication England
Publication date 2004-07-01
ISSN 0007-1250
1472-1465
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Psychiatry
DEXAMETHASONE SUPPRESSION TEST
MAJOR DEPRESSION
STRESS
1ST-EPISODE
PATHOPHYSIOLOGY
SCHIZOPHRENIA
ENLARGEMENT
RECEPTORS
Summary BackgroundPatients with psychosis have activation of the hypothalamic-pituitary-adrenal (HPA) axis during the acute phase of the psychosis. Whether this has any morphological consequences for the pituitary gland is currently unknown.AimsTo examine pituitary volume variation in people at different stages of psychotic disorder.MethodPituitary volume was measured using 1.5 mm, coronal magnetic resonance images in 24 people with first-episode psychosis, 51 with established schizophrenia and 59 healthy controls.ResultsCompared with the control group, the people with first-episode psychosis had pituitary volumes that were 10% larger, whereas those with established schizophrenia had pituitary volumes that were 17% smaller. In both of the groups with psychosis, there was no difference in pituitary volume between those receiving typical antipsychotic drugs and those receiving atypical antipsychotics.ConclusionsThe first episode of a psychosis is associated with a larger pituitary volume, which we suggest is due to activation of the HPA axis. The smaller pituitary volume in the group with established schizophrenia could be the consequence of repeated episodes of HPA axis hyperactivity.
Language eng
DOI 10.1192/bjp.185.1.5
Field of Research 11 Medical and Health Sciences
17 Psychology and Cognitive Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30151264

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.