Structure-Function Relationships in Brain-Injured Patients: A Scoping Review

Parsons, N, Hughes, M, Poudel, G, Dominguez, J and Caeyenberghs, K 2020, Structure-Function Relationships in Brain-Injured Patients: A Scoping Review, MetaArXiv Preprints, pp. 1-36, doi: 10.31222/

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Title Structure-Function Relationships in Brain-Injured Patients: A Scoping Review
Author(s) Parsons, N
Hughes, M
Poudel, G
Dominguez, J
Caeyenberghs, K
Journal name MetaArXiv Preprints
Start page 1
End page 36
Total pages 36
Publisher MetaArXiv Preprints
Publication date 2020-12-08

The human brain is a dynamic network comprised of elements which are structurally connected and functionally interactive. A tight structure-function relationship is vital for this system to produce seamless cognition and behaviour. Brain injuries due to either neurological disease or single-event injuries alter the dynamics of normal structure-function interaction, resulting in poor neurobehavioural outcomes for patients. This scoping review is a synthesis of recent progress in understanding how brain injuries alter the structure-function relationship. We identified 16 studies that investigated the structure-function relationship in brain-injured cohorts, using fMRI and either T1-weighted or diffusion-weighted MRI to calculate, respectively, grey matter density or structural connectivity. Overall, a reduced structure-function relationship was found in brain-injured patients relative to healthy controls. This weakened relationship coincided with impaired cognition. Structural and functional MRI information should also be reconciled into suitable graph theoretical frameworks such as the multilayer network approach

Notes In Press
Language eng
DOI 10.31222/
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
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Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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