Total testosterone is not associated with lean mass or handgrip strength in pre-menopausal females Alexander, Sarah E., Abbott, Gavin, Aisbett, Brad, Wadley, Glenn D., Hnatiuk, Jill A. and Lamon, Severine 2021, Total testosterone is not associated with lean mass or handgrip strength in pre-menopausal females, Scientific reports, vol. 11, pp. 1-9, doi: 10.1038/s41598-021-89232-1. Attached Files Name Description MIMEType Size Downloads Title Total testosterone is not associated with lean mass or handgrip strength in pre-menopausal females Author(s) Alexander, Sarah E. orcid.org/0000-0002-2612-7769 Abbott, Gavin orcid.org/0000-0003-4014-0705 Aisbett, Brad orcid.org/0000-0001-8077-0272 Wadley, Glenn D. orcid.org/0000-0002-6617-4359 Hnatiuk, Jill A. orcid.org/0000-0002-5754-7176 Lamon, Severine orcid.org/0000-0002-3271-6551 Journal name Scientific reports Volume number 11 Article ID 10226 Start page 1 End page 9 Total pages 9 Publisher Nature Publishing Group Place of publication London, Eng. Publication date 2021 ISSN 2045-2322 Keyword(s) Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics HORMONE-BINDING GLOBULIN GROWTH-FACTOR-I SKELETAL-MUSCLE RESISTANCE EXERCISE ANDROGEN RECEPTOR WOMEN SEX PROTEIN INSULIN HYPERANDROGENISM Summary The aim of this study was to examine the relationship between endogenous testosterone concentrations and lean mass and handgrip strength in healthy, pre-menopausal females. Testosterone has been positively associated with lean mass and strength in young and older males. Whether this relationship exists in pre-menopausal females is unknown. Secondary data from the 2013–2014 National Health and Nutrition Examination Survey were used to test this relationship. Females were aged 18–40 (n = 716, age 30 ± 6 years, mean ± SD) and pre-menopausal. Multivariate linear regression models were used to examine associations between total testosterone, lean mass index (LMI) and handgrip strength. Mean ± SD testosterone concentration was 1.0 ± 0.6 nmol L−1 and mean free androgen index (FAI) was 0.02 ± 0.02. In pre-menopausal females, testosterone was not associated with LMI (β = 0.05; 95%CI − 0.04, 0.15; p = 0.237) or handgrip strength (β = 0.01; 95%CI − 0.11, 0.12; p = 0.926) in a statistically significant manner. Conversely, FAI was associated with LMI (β = − 0.03; 95%CI − 0.05, − 0.02; p = 0.000) in a quadratic manner, meaning LMI increases with increasing FAI levels. Handgrip strength was not associated with FAI (β = 0.06; 95%CI − 0.02, 0.15; p = 0.137). These findings indicate that FAI, but not total testosterone, is associated with LMI in pre-menopausal females. Neither FAI nor total testosterone are associated with handgrip strength in pre-menopausal females when testosterone concentrations are not altered pharmacologically. Language eng DOI 10.1038/s41598-021-89232-1 Indigenous content off HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30151423 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Open Access Collection Related Links Link Description Link to full-text (open access)   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 17 May 2021, 08:20:50 EST Mon, 17 May 2021, 16:50:59 EST Tue, 18 May 2021, 05:01:21 EST Tue, 18 May 2021, 08:21:45 EST Sat, 29 May 2021, 02:35:02 EST Sat, 26 Jun 2021, 02:30:28 EST Fri, 02 Jul 2021, 06:08:52 EST Wed, 07 Jul 2021, 15:41:30 EST Wed, 07 Jul 2021, 15:44:13 EST Filtered Full Citation counts:   Cited 3 times in TR Web of Science Cited 3 times in Scopus Search Google Scholar Access Statistics: 139 Abstract Views, 1 File Downloads  -  Detailed Statistics Created: Mon, 17 May 2021, 16:50:59 EST