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Total testosterone is not associated with lean mass or handgrip strength in pre-menopausal females

Alexander, Sarah E., Abbott, Gavin, Aisbett, Brad, Wadley, Glenn D., Hnatiuk, Jill A. and Lamon, Severine 2021, Total testosterone is not associated with lean mass or handgrip strength in pre-menopausal females, Scientific reports, vol. 11, pp. 1-9, doi: 10.1038/s41598-021-89232-1.

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Title Total testosterone is not associated with lean mass or handgrip strength in pre-menopausal females
Author(s) Alexander, Sarah E.ORCID iD for Alexander, Sarah E. orcid.org/0000-0002-2612-7769
Abbott, GavinORCID iD for Abbott, Gavin orcid.org/0000-0003-4014-0705
Aisbett, BradORCID iD for Aisbett, Brad orcid.org/0000-0001-8077-0272
Wadley, Glenn D.ORCID iD for Wadley, Glenn D. orcid.org/0000-0002-6617-4359
Hnatiuk, Jill A.ORCID iD for Hnatiuk, Jill A. orcid.org/0000-0002-5754-7176
Lamon, SeverineORCID iD for Lamon, Severine orcid.org/0000-0002-3271-6551
Journal name Scientific reports
Volume number 11
Article ID 10226
Start page 1
End page 9
Total pages 9
Publisher Nature Publishing Group
Place of publication London, Eng.
Publication date 2021
ISSN 2045-2322
Keyword(s) Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
HORMONE-BINDING GLOBULIN
GROWTH-FACTOR-I
SKELETAL-MUSCLE
RESISTANCE EXERCISE
ANDROGEN RECEPTOR
WOMEN
SEX
PROTEIN
INSULIN
HYPERANDROGENISM
Summary The aim of this study was to examine the relationship between endogenous testosterone concentrations and lean mass and handgrip strength in healthy, pre-menopausal females. Testosterone has been positively associated with lean mass and strength in young and older males. Whether this relationship exists in pre-menopausal females is unknown. Secondary data from the 2013–2014 National Health and Nutrition Examination Survey were used to test this relationship. Females were aged 18–40 (n = 716, age 30 ± 6 years, mean ± SD) and pre-menopausal. Multivariate linear regression models were used to examine associations between total testosterone, lean mass index (LMI) and handgrip strength. Mean ± SD testosterone concentration was 1.0 ± 0.6 nmol L−1 and mean free androgen index (FAI) was 0.02 ± 0.02. In pre-menopausal females, testosterone was not associated with LMI (β = 0.05; 95%CI − 0.04, 0.15; p = 0.237) or handgrip strength (β = 0.01; 95%CI − 0.11, 0.12; p = 0.926) in a statistically significant manner. Conversely, FAI was associated with LMI (β = − 0.03; 95%CI − 0.05, − 0.02; p = 0.000) in a quadratic manner, meaning LMI increases with increasing FAI levels. Handgrip strength was not associated with FAI (β = 0.06; 95%CI − 0.02, 0.15; p = 0.137). These findings indicate that FAI, but not total testosterone, is associated with LMI in pre-menopausal females. Neither FAI nor total testosterone are associated with handgrip strength in pre-menopausal females when testosterone concentrations are not altered pharmacologically.
Language eng
DOI 10.1038/s41598-021-89232-1
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30151423

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.