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Liver-derived IGF-I regulates cortical bone mass but is dispensable for the osteogenic response to mechanical loading in female mice

Svensson, Johan, Windahl, Sara H, Saxon, Leanne, Sjögren, Klara, Koskela, Antti, Tuukkanen, Juha and Ohlsson, Claes 2016, Liver-derived IGF-I regulates cortical bone mass but is dispensable for the osteogenic response to mechanical loading in female mice, American journal of physiology: endocrinology and metabolism, vol. 311, no. 1, pp. E138-E144, doi: 10.1152/ajpendo.00107.2016.

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Title Liver-derived IGF-I regulates cortical bone mass but is dispensable for the osteogenic response to mechanical loading in female mice
Author(s) Svensson, Johan
Windahl, Sara H
Saxon, Leanne
Sjögren, Klara
Koskela, Antti
Tuukkanen, Juha
Ohlsson, Claes
Journal name American journal of physiology: endocrinology and metabolism
Volume number 311
Issue number 1
Start page E138
End page E144
Total pages 7
Publisher American Physiological Society
Place of publication Bethesda, Md.
Publication date 2016-07
ISSN 0193-1849
1522-1555
Keyword(s) insulin-like growth factor-I
liver-derived
mechanical loading
cortical bone mass
cortical porosity
Summary Low circulating IGF-I is associated with increased fracture risk. Conditional depletion of IGF-I produced in osteoblasts or osteocytes inhibits the bone anabolic effect of mechanical loading. Here, we determined the role of endocrine IGF-I for the osteogenic response to mechanical loading in young adult and old female mice with adult, liver-specific IGF-I inactivation (LI-IGF-I−/− mice, serum IGF-I reduced by ≈70%) and control mice. The right tibia was subjected to short periods of axial cyclic compressive loading three times/wk for 2 wk, and measurements were performed using microcomputed tomography and mechanical testing by three-point bending. In the nonloaded left tibia, the LI-IGF-I−/− mice had lower cortical bone area and increased cortical porosity, resulting in reduced bone mechanical strength compared with the controls. Mechanical loading induced a similar response in LI-IGF-I−/− and control mice in terms of cortical bone area and trabecular bone volume fraction. In fact, mechanical loading produced a more marked increase in cortical bone mechanical strength, which was associated with a less marked increase in cortical porosity, in the LI-IGF-I−/− mice compared with the control mice. In conclusion, liver-derived IGF-I regulates cortical bone mass, cortical porosity, and mechanical strength under normal (nonloaded) conditions. However, despite an ∼70% reduction in circulating IGF-I, the osteogenic response to mechanical loading was not attenuated in the LI-IGF-I−/− mice.
Language eng
DOI 10.1152/ajpendo.00107.2016
Indigenous content off
Field of Research 06 Biological Sciences
11 Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30151510

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.