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The development of structural covariance networks during the transition from childhood to adolescence

Vijayakumar, Nandita, Ball, G, Seal, M L, Mundy, L, Whittle, S and Silk, Tim 2021, The development of structural covariance networks during the transition from childhood to adolescence, Scientific reports, vol. 11, pp. 1-12, doi: 10.1038/s41598-021-88918-w.

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Title The development of structural covariance networks during the transition from childhood to adolescence
Author(s) Vijayakumar, NanditaORCID iD for Vijayakumar, Nandita orcid.org/0000-0002-5622-9547
Ball, G
Seal, M L
Mundy, L
Whittle, S
Silk, TimORCID iD for Silk, Tim orcid.org/0000-0002-7290-512X
Journal name Scientific reports
Volume number 11
Article ID 9451
Start page 1
End page 12
Total pages 12
Publisher Nature
Place of publication London, Eng.
Publication date 2021
ISSN 2045-2322
2045-2322
Keyword(s) BRAIN-DEVELOPMENT
CEREBRAL-CORTEX
CONNECTIVITY
CORTICAL THICKNESS
GRAY-MATTER
LIFE-SPAN
LONGITUDINAL ANALYSIS
Multidisciplinary Sciences
ORGANIZATION
Science & Technology
Science & Technology - Other Topics
SURFACE-AREA
TRAJECTORIES
Summary Structural covariance conceptualizes how morphologic properties of brain regions are related to one another (across individuals). It can provide unique information to cortical structure (e.g., thickness) about the development of functionally meaningful networks. The current study investigated how structural covariance networks develop during the transition from childhood to adolescence, a period characterized by marked structural re-organization. Participants (N = 192; scans = 366) completed MRI assessments between 8.5 and 14.5 years of age. A sliding window approach was used to create “age-bins”, and structural covariance networks (based on cortical thickness) were created for each bin. Next, generalized additive models were used to characterize trajectories of age-related changes in network properties. Results revealed nonlinear trajectories with “peaks” in mean correlation and global density that are suggestive of a period of convergence in anatomical properties across the cortex during early adolescence, prior to regional specialization. “Hub” regions in sensorimotor cortices were present by late childhood, but the extent and strength of association cortices as “hubs” increased into mid-adolescence. Moreover, these regional changes were found to be related to rates of thinning across the cortex. In the context of neurocognitive networks, the frontoparietal, default mode, and attention systems exhibited age-related increases in within-network and between-network covariance. These regional and modular developmental patterns are consistent with continued refinement of socioemotional and other complex executive functions that are supported by higher-order cognitive networks during early adolescence.
Language eng
DOI 10.1038/s41598-021-88918-w
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30151709

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.