Depressive psychopathology in first-episode schizophrenia spectrum disorders: A systematic review, meta-analysis and meta-regression

Herniman, Sarah E., Allott, Kelly, Phillips, Lisa J, Wood, Stephen J, Uren, Jacqueline, Mallawaarachchi, Sumudu R and Cotton, Sue M 2019, Depressive psychopathology in first-episode schizophrenia spectrum disorders: A systematic review, meta-analysis and meta-regression, Psychological medicine, vol. 49, no. 15, pp. 2463-2474, doi: 10.1017/S0033291719002344.

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Title Depressive psychopathology in first-episode schizophrenia spectrum disorders: A systematic review, meta-analysis and meta-regression
Author(s) Herniman, Sarah E.
Allott, Kelly
Phillips, Lisa J
Wood, Stephen J
Uren, Jacqueline
Mallawaarachchi, Sumudu R
Cotton, Sue M
Journal name Psychological medicine
Volume number 49
Issue number 15
Start page 2463
End page 2474
Total pages 12
Publisher Cambridge University Press
Place of publication Cambridge, Eng.
Publication date 2019-11
ISSN 0033-2917
1469-8978
Keyword(s) Social Sciences
Science & Technology
Life Sciences & Biomedicine
Psychology, Clinical
Psychiatry
Psychology
Caseness
comorbidity
depression
disorder
psychosis
symptoms
1ST EPISODE SCHIZOPHRENIA
CLINICAL CHARACTERISTICS
FOLLOW-UP
PSYCHOTIC SYMPTOMS
EARLY INTERVENTION
NEGATIVE SYMPTOMS
PREVALENCE
PREDICTORS
EFFICACY
SAFETY
Summary Background:
Despite knowing for many decades that depressive psychopathology is common in first-episode schizophrenia spectrum disorders (FES), there is limited knowledge regarding the extent and nature of such psychopathology (degree of comorbidity, caseness, severity) and its demographic, clinical, functional and treatment correlates. This study aimed to determine the pooled prevalence of depressive disorder and caseness, and the pooled mean severity of depressive symptoms, as well as the demographic, illness, functional and treatment correlates of depressive psychopathology in FES.
Methods:
This systematic review, meta-analysis and meta-regression was prospectively registered (CRD42018084856) and conducted in accordance with PRISMA and MOOSE guidelines. Results:
Forty studies comprising 4041 participants were included. The pooled prevalence of depressive disorder and caseness was 26.0% (seven samples, N = 855, 95% CI 22.1-30.3) and 43.9% (11 samples, N = 1312, 95% CI 30.3-58.4), respectively. The pooled mean percentage of maximum depressive symptom severity was 25.1 (38 samples, N = 3180, 95% CI 21.49-28.68). Correlates of depressive psychopathology were also found. Conclusions:
At least one-quarter of individuals with FES will experience, and therefore require treatment for, a full-threshold depressive disorder. Nearly half will experience levels of depressive symptoms that are severe enough to warrant diagnostic investigation and therefore clinical intervention - regardless of whether they actually fulfil diagnostic criteria for a depressive disorder. Depressive psychopathology is prominent in FES, manifesting not only as superimposed comorbidity, but also as an inextricable symptom domain.
Language eng
DOI 10.1017/S0033291719002344
Indigenous content off
Field of Research 1109 Neurosciences
1117 Public Health and Health Services
1701 Psychology
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30151768

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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