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Dynamic control of neurochemical release with ultrasonically-sensitive nanoshell-tethered liposomes

Mackay, SM, Myint, DMA, Easingwood, RA, Hegh, Dylan, Wickens, JR, Hyland, BI, Jameson, GNL, Reynolds, JNJ and Tan, EW 2019, Dynamic control of neurochemical release with ultrasonically-sensitive nanoshell-tethered liposomes, Communications Chemistry, vol. 2, no. 1, pp. 1-10, doi: 10.1038/s42004-019-0226-0.

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Title Dynamic control of neurochemical release with ultrasonically-sensitive nanoshell-tethered liposomes
Author(s) Mackay, SM
Myint, DMA
Easingwood, RA
Hegh, Dylan
Wickens, JR
Hyland, BI
Jameson, GNL
Reynolds, JNJ
Tan, EW
Journal name Communications Chemistry
Volume number 2
Issue number 1
Article ID 122
Start page 1
End page 10
Total pages 10
Publisher Springer
Place of publication Amsterdam, The Netherlands
Publication date 2019
ISSN 2399-3669
Summary Abstract The unique surface plasmon resonance of hollow gold nanoshells can be used to achieve drug release from liposomes upon laser stimulation, and adapted to mimic the intricate dynamics of neurotransmission ex vivo in brain preparations. However, to induce a physiological response in vivo requires the degree of temporal precision afforded by laser stimulation, but with a greater depth of penetration through tissue. Here we report that the attachment of hollow gold nanoshells to the surface of robust liposomes results in a construct that is highly sensitive to ultrasonic stimulation. The resulting construct can be remotely triggered by low intensity, therapeutic ultrasound. To our knowledge, this is the first example of nanoparticle-liposome system that can be activated by both laser and acoustic stimulation. The system is capable of encapsulating the neurochemical dopamine, and repeatedly releasing small amounts on-demand in a circulating environment, allowing for precise spatiotemporal control over the release profile.
Language eng
DOI 10.1038/s42004-019-0226-0
HERDC Research category C1.1 Refereed article in a scholarly journal
Grant ID Otago Doctoral Scholarship
Rutherford Discovery Fellowship from the Royal Society of New Zealand
Foundation of Research, Science and Technology
Ministry of Science and Innovation (NERF Grant no. UOOX0807)
Ministry of Business, Innovation and Employment (Smart Ideas Phase 1; No. UOOX1403)
Otago Medical Research Foundation and Otago Innovation Ltd
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30151938

Document type: Journal Article
Collections: Institute for Frontier Materials
Open Access Collection
GTP Research
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.