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Associations of health-related quality of life, fear of falling and objective measures of physical function with bone health in postmenopausal women with low bone mass

Gandham, Anoohya, McMillan, Lachlan B, Ng, Carrie-Anne, Humbert, Ludovic, Bonham, Maxine P, Zengin, Ayse, Ebeling, Peter R and Scott, David 2019, Associations of health-related quality of life, fear of falling and objective measures of physical function with bone health in postmenopausal women with low bone mass, Journal of clinical medicine, vol. 8, no. 9, pp. 1-13, doi: 10.3390/jcm8091370.

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Title Associations of health-related quality of life, fear of falling and objective measures of physical function with bone health in postmenopausal women with low bone mass
Author(s) Gandham, Anoohya
McMillan, Lachlan B
Ng, Carrie-Anne
Humbert, Ludovic
Bonham, Maxine P
Zengin, Ayse
Ebeling, Peter R
Scott, DavidORCID iD for Scott, David orcid.org/0000-0001-5226-1972
Journal name Journal of clinical medicine
Volume number 8
Issue number 9
Article ID 1370
Start page 1
End page 13
Total pages 13
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2019-09
ISSN 2077-0383
2077-0383
Keyword(s) bone
General & Internal Medicine
health-related quality of life
Life Sciences & Biomedicine
Medicine, General & Internal
osteoporosis
physical function
postmenopausal women
Science & Technology
Summary Health-related quality of life (HRQoL) and physical function deteriorate with age and may adversely impact bone health in older adults. We determined associations of objective measures of physical function and HRQoL with bone health in postmenopausal women with low areal bone mineral density (aBMD). Fifty postmenopausal women (64.4 7.7 years old, mean standard deviation) with low spine, hip or femoral neck aBMD (T- or Z-score < −1.0) on dual-energy X-ray absorptiometry (DXA) participated. Femoral surface BMD, trabecular, integral and cortical volumetric BMD (vBMD) measurements were obtained using 3D-SHAPER software on DXA. Distal tibial vBMD and microarchitecture were assessed using high-resolution peripheral quantitative computed tomography (HRpQCT). Participants completed self-administered EuroQol-5D (EQ-5D) and modified falls efficacy scale (MFES) questionnaires, and physical function assessments. Stair climb power was positively associated with bone parameters at the hip, femoral neck, and distal tibia (all p < 0.05) in multivariable linear regression. EQ-5D demonstrated no significant associations with bone parameters and MFES was positively associated only with distal tibial cortical vBMD and cortical von Mises stress (both p < 0.05). Objective measures of physical function, particularly muscle power, are more consistently associated with bone parameters compared with self-administered HRQoL questionnaires.
Language eng
DOI 10.3390/jcm8091370
Indigenous content off
Field of Research 1103 Clinical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30151975

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.