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The relationship between vitamin d metabolites and androgens in women with polycystic ovary syndrome

Mesinovic, Jakub, Teede, Helena J., Shorakae, Soulmaz, Lambert, Gavin W., Lambert, Elisabeth A., Naderpoor, Negar and de Courten, Barbora 2020, The relationship between vitamin d metabolites and androgens in women with polycystic ovary syndrome, Nutrients, vol. 12, no. 5, pp. 1-8, doi: 10.3390/nu12051219.

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Title The relationship between vitamin d metabolites and androgens in women with polycystic ovary syndrome
Author(s) Mesinovic, Jakub
Teede, Helena J.
Shorakae, Soulmaz
Lambert, Gavin W.
Lambert, Elisabeth A.
Naderpoor, Negar
de Courten, Barbora
Journal name Nutrients
Volume number 12
Issue number 5
Article ID 1219
Start page 1
End page 8
Total pages 8
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2020
ISSN 2072-6643
2072-6643
Keyword(s) 25-HYDROXYVITAMIN D
androgens
ANTI-MULLERIAN HORMONE
D-BINDING PROTEIN
ENDOCRINE
EXCESS
FSH
Life Sciences & Biomedicine
Nutrition & Dietetics
polycystic ovary syndrome
Science & Technology
SERUM
STEROIDOGENESIS
SUPPLEMENTATION
testosterone
vitamin D
vitamin D-binding protein
Summary Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age, with hyperandrogenism present in up to 90% of affected women. Some evidence suggests a link between vitamin D deficiency and PCOS features via insulin resistance and inflammation. Our aim was to explore the relationship between biochemical markers of vitamin D status and androgens in women with PCOS. This cross-sectional study used bio-banked samples from 46 pre-menopausal women with PCOS (mean ± SD: age 30 ± 6 years; BMI 29 ± 6 kg/m2). We measured 25-hydroxyvitamin D (25[OH]D), vitamin D-binding protein (DBP), total testosterone, sex hormone-binding globulin (SHBG), and calculated the free androgen index (FAI) and bioavailable and free 25(OH)D. Fasting glucose and insulin were used to calculate the homeostatic model assessment of insulin resistance (HOMA-IR) and body fat percentage was determined via dual energy x-ray absorptiometry. High-sensitivity C-reactive protein (hs-CRP) was measured as a marker of inflammation. DBP was positively associated with total 25(OH)D and expectedly, negatively associated with free 25(OH)D. There were no associations between vitamin D metabolites and total testosterone, SHBG or FAI, even after adjusting for age, body fat percentage, HOMA-IR and hs-CRP. We found no associations between vitamin D metabolites and androgens in women with PCOS. Studies that have identified a vitamin D–androgen link have largely relied on methodology with numerous pitfalls; future studies should exclusively use gold-standard measures to confirm these findings in this population.
Language eng
DOI 10.3390/nu12051219
Indigenous content off
Field of Research 0908 Food Sciences
1111 Nutrition and Dietetics
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30152028

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.