Disruption of circadian rhythm and risk of autism spectrum disorder: Role of immune-inflammatory, oxidative stress, metabolic and neurotransmitter pathways Abdul, F, Sreenivas, N, Kommu, JVS, Banerjee, M, Berk, Michael, Maes, M, Leboyer, M and Debnath, M 2022, Disruption of circadian rhythm and risk of autism spectrum disorder: Role of immune-inflammatory, oxidative stress, metabolic and neurotransmitter pathways, Reviews in the Neurosciences, vol. 33, no. 1, pp. 93-109, doi: 10.1515/revneuro-2021-0022. Attached Files Name Description MIMEType Size Downloads Title Disruption of circadian rhythm and risk of autism spectrum disorder: Role of immune-inflammatory, oxidative stress, metabolic and neurotransmitter pathways Author(s) Abdul, F Sreenivas, N Kommu, JVS Banerjee, M Berk, Michael orcid.org/0000-0002-5554-6946 Maes, M Leboyer, M Debnath, M Journal name Reviews in the Neurosciences Volume number 33 Issue number 1 Start page 93 End page 109 Total pages 17 Publisher WALTER DE GRUYTER GMBH Place of publication Germany Publication date 2022-01-01 ISSN 0334-1763 2191-0200 Keyword(s) Science & Technology Life Sciences & Biomedicine Neurosciences Neurosciences & Neurology autism circadian rhythm neurodevelopmental neuro-immune neurotransmitter oxidative stress CLOCK GENES GUT-MICROBIOTA DOPAMINE TRANSPORTER ANTIOXIDANT ENZYMES REV-ERB CHILDREN SLEEP CORTISOL MELATONIN BRAIN Summary Abstract Circadian rhythms in most living organisms are regulated by light and synchronized to an endogenous biological clock. The circadian clock machinery is also critically involved in regulating and fine-tuning neurodevelopmental processes. Circadian disruption during embryonic development can impair crucial phases of neurodevelopment. This can contribute to neurodevelopmental disorders like autism spectrum disorder (ASD) in the offspring. Increasing evidence from studies showing abnormalities in sleep and melatonin as well as genetic and epigenetic changes in the core elements of the circadian pathway indicate a pivotal role of circadian disruption in ASD. However, the underlying mechanistic basis through which the circadian pathways influence the risk and progression of ASD are yet to be fully discerned. Well-recognized mechanistic pathways in ASD include altered immune-inflammatory, nitro oxidative stress, neurotransmission and synaptic plasticity, and metabolic pathways. Notably, all these pathways are under the control of the circadian clock. It is thus likely that a disrupted circadian clock will affect the functioning of these pathways. Herein, we highlight the possible mechanisms through which aberrations in the circadian clock might affect immune-inflammatory, nitro-oxidative, metabolic pathways, and neurotransmission, thereby driving the neurobiological sequelae leading to ASD. Language eng DOI 10.1515/revneuro-2021-0022 Field of Research 110999 Neurosciences not elsewhere classified 1109 Neurosciences 1701 Psychology 1702 Cognitive Sciences Socio Economic Objective 920410 Mental Health HERDC Research category C1 Refereed article in a scholarly journal Persistent URL http://hdl.handle.net/10536/DRO/DU:30152144 Document type: Journal Article Collections: Faculty of Health School of Medicine Related Links Link Description Connect to published version Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Fri, 04 Jun 2021, 15:42:53 EST Sat, 05 Jun 2021, 05:02:06 EST Sat, 19 Jun 2021, 02:43:12 EST Thu, 15 Jul 2021, 06:07:45 EST Thu, 22 Jul 2021, 13:09:29 EST Thu, 22 Jul 2021, 13:12:14 EST Sat, 29 Jan 2022, 01:30:29 EST Wed, 23 Mar 2022, 12:11:28 EST Filtered Full Citation counts:   Cited 3 times in TR Web of Science Cited 3 times in Scopus Search Google Scholar Access Statistics: 112 Abstract Views, 1 File Downloads  -  Detailed Statistics Created: Fri, 04 Jun 2021, 15:42:53 EST