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Disruption of circadian rhythm and risk of autism spectrum disorder: Role of immune-inflammatory, oxidative stress, metabolic and neurotransmitter pathways

Abdul, F, Sreenivas, N, Kommu, JVS, Banerjee, M, Berk, Michael, Maes, M, Leboyer, M and Debnath, M 2022, Disruption of circadian rhythm and risk of autism spectrum disorder: Role of immune-inflammatory, oxidative stress, metabolic and neurotransmitter pathways, Reviews in the Neurosciences, vol. 33, no. 1, pp. 93-109, doi: 10.1515/revneuro-2021-0022.

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Title Disruption of circadian rhythm and risk of autism spectrum disorder: Role of immune-inflammatory, oxidative stress, metabolic and neurotransmitter pathways
Author(s) Abdul, F
Sreenivas, N
Kommu, JVS
Banerjee, M
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Maes, M
Leboyer, M
Debnath, M
Journal name Reviews in the Neurosciences
Volume number 33
Issue number 1
Start page 93
End page 109
Total pages 17
Publisher WALTER DE GRUYTER GMBH
Place of publication Germany
Publication date 2022-01-01
ISSN 0334-1763
2191-0200
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
autism
circadian rhythm
neurodevelopmental
neuro-immune
neurotransmitter
oxidative stress
CLOCK GENES
GUT-MICROBIOTA
DOPAMINE TRANSPORTER
ANTIOXIDANT ENZYMES
REV-ERB
CHILDREN
SLEEP
CORTISOL
MELATONIN
BRAIN
Summary Abstract Circadian rhythms in most living organisms are regulated by light and synchronized to an endogenous biological clock. The circadian clock machinery is also critically involved in regulating and fine-tuning neurodevelopmental processes. Circadian disruption during embryonic development can impair crucial phases of neurodevelopment. This can contribute to neurodevelopmental disorders like autism spectrum disorder (ASD) in the offspring. Increasing evidence from studies showing abnormalities in sleep and melatonin as well as genetic and epigenetic changes in the core elements of the circadian pathway indicate a pivotal role of circadian disruption in ASD. However, the underlying mechanistic basis through which the circadian pathways influence the risk and progression of ASD are yet to be fully discerned. Well-recognized mechanistic pathways in ASD include altered immune-inflammatory, nitro oxidative stress, neurotransmission and synaptic plasticity, and metabolic pathways. Notably, all these pathways are under the control of the circadian clock. It is thus likely that a disrupted circadian clock will affect the functioning of these pathways. Herein, we highlight the possible mechanisms through which aberrations in the circadian clock might affect immune-inflammatory, nitro-oxidative, metabolic pathways, and neurotransmission, thereby driving the neurobiological sequelae leading to ASD.
Language eng
DOI 10.1515/revneuro-2021-0022
Field of Research 110999 Neurosciences not elsewhere classified
1109 Neurosciences
1701 Psychology
1702 Cognitive Sciences
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30152144

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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Created: Fri, 04 Jun 2021, 15:42:53 EST

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