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Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies possible targets of allele-specific immunity to clinical malaria

Shah, Zalak, Naung, Myo T, Moser, Kara A, Adams, Matthew, Buchwald, Andrea G, Dwivedi, Ankit, Ouattara, Amed, Seydel, Karl B, Mathanga, Don P, Barry, Alyssa E, Serre, David, Laufer, Miriam K, Silva, Joana C and Takala-Harrison, Shannon 2021, Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies possible targets of allele-specific immunity to clinical malaria, PLoS genetics, vol. 17, no. 5, pp. 1-20, doi: 10.1371/journal.pgen.1009576.

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Title Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies possible targets of allele-specific immunity to clinical malaria
Author(s) Shah, Zalak
Naung, Myo T
Moser, Kara A
Adams, Matthew
Buchwald, Andrea G
Dwivedi, Ankit
Ouattara, Amed
Seydel, Karl B
Mathanga, Don P
Barry, Alyssa EORCID iD for Barry, Alyssa E orcid.org/0000-0002-1189-2310
Serre, David
Laufer, Miriam K
Silva, Joana C
Takala-Harrison, Shannon
Journal name PLoS genetics
Volume number 17
Issue number 5
Article ID e1009576
Start page 1
End page 20
Total pages 20
Publisher Public Library of Science
Place of publication San Francisco, Calif.
Publication date 2021-05-25
ISSN 1553-7390
1553-7404
Keyword(s) Genetics & Heredity
Life Sciences & Biomedicine
Science & Technology
Immunity
Parasitic diseases
Malaria
Cloning
Genomics
Vaccines
Immune response
infectious disease immunology
Summary Individuals acquire immunity to clinical malaria after repeated Plasmodium falciparum infections. Immunity to disease is thought to reflect the acquisition of a repertoire of responses to multiple alleles in diverse parasite antigens. In previous studies, we identified polymorphic sites within individual antigens that are associated with parasite immune evasion by examining antigen allele dynamics in individuals followed longitudinally. Here we expand this approach by analyzing genome-wide polymorphisms using whole genome sequence data from 140 parasite isolates representing malaria cases from a longitudinal study in Malawi and identify 25 genes that encode possible targets of naturally acquired immunity that should be validated immunologically and further characterized for their potential as vaccine candidates.
Language eng
DOI 10.1371/journal.pgen.1009576
Indigenous content off
Field of Research 0604 Genetics
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30152163

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.