Inhibiting IL-6 During Cytokine Storm in COVID-19: Potential Role of Natural Products

Nasirzadeh, A, Jafarzadeh Maivan, MH, Bazeli, J, Hajavi, J, Yavarmanesh, N, Zahedi, M, Abounoori, M, Razavi, A, Maddah, MM, Mortazavi, P, Moradi, M, Heidarzadeh, S, Mardaneh, J, Shoeibi, A, Alizadehsani, Roohallah and Shariful Islam, Sheikh 2021, Inhibiting IL-6 During Cytokine Storm in COVID-19: Potential Role of Natural Products, Preprints, pp. 1-21, doi: 10.20944/preprints202106.0131.v1.

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Title Inhibiting IL-6 During Cytokine Storm in COVID-19: Potential Role of Natural Products
Author(s) Nasirzadeh, A
Jafarzadeh Maivan, MH
Bazeli, J
Hajavi, J
Yavarmanesh, N
Zahedi, M
Abounoori, M
Razavi, A
Maddah, MM
Mortazavi, P
Moradi, M
Heidarzadeh, S
Mardaneh, J
Shoeibi, A
Alizadehsani, Roohallah
Shariful Islam, SheikhORCID iD for Shariful Islam, Sheikh orcid.org/0000-0001-7926-9368
Journal name Preprints
Start page 1
End page 21
Total pages 21
Publisher Preprints
Publication date 2021-06-04
Keyword(s) COVID-19
Cytokine storm
IL-6
Natural product
Summary Plant species with anti-inflammatory properties might play an essential role in combatting COVID-19 via reducing cytokine storms. We aimed to review the extant evidence of the potential therapeutic efficacy of natural products against cytokine storms by inhibiting interleukin-6 (IL-6) as a major pathological mediator. Data were collected following an electronic search in major databases (Pubmed, Scopus, Web of Science, Google Scholar) and also preprint articles on preprint and medRxiv servers by using a combination of relevant keywords. Seventeen active compounds and medicinal plants were found and reviewed in the present review. Results of both in-vivo and in-vitro experiments conducted on these compounds showed that Phillyrin, SMFM, Qiangzhi decoction, curcumin, Shen-Fu, Forsythia, and Alpha-Mangostin inhibit the production of IL-6. Andrographolide and Liu Shen Wan have an inhibitory effect on releasing this agent, while Ilex Asprella and Deoxy-11,12-didehydroandrographolide and naringin reduce the expression of IL-6. Theaflavin and Cholorogenic acid inhibit the secretion of IL-6, Xuebijing, and Chai-Hu-Gui-Zi-Gan-Jiang-Tang and Lipanpaidu prescription can reduce the serum level of IL-6. These agents also effectively improve infected lungs, increase survival rates, and minimize tissue damage. Medicinal plants and their phytochemical ingredients with down-regulatory effects on the expression of IL-6 have a potential influence on the inhibition of cytokine storms during viral infection caused by COVID-19. Therefore, phytochemicals could be regarded as promising candidates for managing cytokine storm inflammatory responses due to COVID-19 infection.
Notes In Press
Language eng
DOI 10.20944/preprints202106.0131.v1
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30152343

Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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