Inhibiting NF-κB during cytokine storm in COVID-19: potential role of natural products as a promising therapeutic approach

Mardaneh, Jalal, Nasirzadeh, Amirreza, Bazeli, Javad, Hajavi, Jafar, Zahedi, Mohammad, Abounoori, Mahdi, Razavi, Alireza, Maddah, Mohammad Moein, Mortazavi, Parham, Moradi, Mohammad, Salehi, Fatemah, Heidarzadeh, Siamak, Jafarzadeh Maivan, Mohammad Hosein, Shoeibi, Afshin, Alizadehsani, Roohallah and Shariful Islam, Sheikh Mohammed 2021, Inhibiting NF-κB during cytokine storm in COVID-19: potential role of natural products as a promising therapeutic approach, [Unknown], pp. 1-35, doi: 10.20944/preprints202106.0130.v1.

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Title Inhibiting NF-κB during cytokine storm in COVID-19: potential role of natural products as a promising therapeutic approach
Author(s) Mardaneh, Jalal
Nasirzadeh, Amirreza
Bazeli, Javad
Hajavi, Jafar
Zahedi, Mohammad
Abounoori, Mahdi
Razavi, Alireza
Maddah, Mohammad Moein
Mortazavi, Parham
Moradi, Mohammad
Salehi, Fatemah
Heidarzadeh, Siamak
Jafarzadeh Maivan, Mohammad Hosein
Shoeibi, Afshin
Alizadehsani, Roohallah
Shariful Islam, Sheikh MohammedORCID iD for Shariful Islam, Sheikh Mohammed orcid.org/0000-0001-7926-9368
Journal name [Unknown]
Start page 1
End page 35
Total pages 35
Publisher [Unknown]
Place of publication [Unknown]
Publication date 2021-06-04
Keyword(s) COVID-19
Pandemic
Natural Products
NF-KB
Summary Many inflammatory mechanisms are involved in the pathophysiology of COVID-19 infection. COVID-19 inhibits IFN antiviral responses, so we should expect an out-of-control viral replication. “Cytokine storms” occur due to the over-production of pro-inflammatory cytokines after an influx of neutrophils and monocytes/macrophages and may be responsible for the immunopathology of the lung involvement. Several cascades have been reported in the activation process of NF-κB. In this paper, to find new therapeutic options for COVID-19 infection, we reviewed some natural products that could potentially inhibit the NF-κB pathway. We found that sevoflurane, quercetin, resveratrol, curcumin, KIOM-C, bergenin, garcinia kola, shenfu, piperlongumine, wogonin, oroxylin, plantamajoside, naringin, ginseng, kaempferol, allium sativum L, illicium henryi, isoliquiritigenin, lianhua qingwen, magnoflorine, and ma Huang Tang might be effective in inhibiting the NF-KB pathway. These natural products could be helpful in the control of COVID-19 infections. However, larger clinical trials are needed to ascertain the efficacy of these products fully.
Notes Preprint version, not peer-reviewed
Language eng
DOI 10.20944/preprints202106.0130.v1
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30152355

Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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