Polypropylene-nanodiamond composite for hernia mesh

Houshyar, S, Sarker, A, Jadhav, A, Kumar, GS, Bhattacharyya, A, Nayak, R, Shanks, RA, Saha, T, Rifai, Mohamed, Padhye, R and Fox, K 2020, Polypropylene-nanodiamond composite for hernia mesh, Materials Science and Engineering C, vol. 111, pp. 1-10, doi: 10.1016/j.msec.2020.110780.

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Title Polypropylene-nanodiamond composite for hernia mesh
Author(s) Houshyar, S
Sarker, A
Jadhav, A
Kumar, GS
Bhattacharyya, A
Nayak, R
Shanks, RA
Saha, T
Rifai, Mohamed
Padhye, R
Fox, K
Journal name Materials Science and Engineering C
Volume number 111
Start page 1
End page 10
Total pages 10
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2020-06
ISSN 0928-4931
Keyword(s) Hernia mesh
Protein absorption
Nanocomposite fibre
Biomedical materials
Science & Technology
Materials Science, Biomaterials
Materials Science
Summary Commercial hernia mesh is commonly made from polypropylene (PP), due to its inertness, biocompatibility, physical properties, ease of processing and versatility for conversion into flexible shape. However, reportedly hernia mesh prepared from PP experienced issues such as diminished long-term strength, foreign body rejection, lack of biocompatibility and high adhesion to the abdomen wall. Infiltration of the mesh by soft tissue (called remodeling) results in an integration of mesh into the body, leading to a rapid reduction in mesh mechanical properties and potential infection. Here, this study addresses these issues through the incorporation of nanodiamond (ND) into PP filament and coating on the surface of plasma-treated PP-ND mesh. The results show that the dynamic modulus of the PP-ND mesh increased significantly, without compromising its flexibility. Coating PP-ND mesh with hydroxylated ND led to a reduction in nonspecific protein adsorption onto the surface of nanocomposite, which is an important characteristic for hernia mesh to prevent foreign body reaction, attachment of mesh to the abdominal wall and nearby organs. In-vitro study with mammalian cells shows that coated PP-ND mesh with functionalized ND exhibits a significant increase in the number of adhered cells with more elongated morphology in comparison with other PP meshes, due to the better hydrophilicity. Therefore, the ND coated nanocomposite mesh can be a promising candidate for hernia repair in the future; however, more investigation is required.
Language eng
DOI 10.1016/j.msec.2020.110780
Field of Research 0903 Biomedical Engineering
0912 Materials Engineering
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30152384

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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