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Premotor dorsal white matter integrity for the prediction of upper limb motor impairment after stroke

Boccuni, L, Meyer, S, D’cruz, N, Kessner, S S, Marinelli, L, Trompetto, C, Peeters, Anna, Van Pesch, V, Duprez, T, Sunaert, S, Feys, H, Thijs, V, Nieuwboer, A and Verheyden, G 2019, Premotor dorsal white matter integrity for the prediction of upper limb motor impairment after stroke, Scientific Reports, vol. 9, pp. 1-9, doi: 10.1038/s41598-019-56334-w.

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Title Premotor dorsal white matter integrity for the prediction of upper limb motor impairment after stroke
Author(s) Boccuni, L
Meyer, S
D’cruz, N
Kessner, S S
Marinelli, L
Trompetto, C
Peeters, AnnaORCID iD for Peeters, Anna orcid.org/0000-0003-4340-9132
Van Pesch, V
Duprez, T
Sunaert, S
Feys, H
Thijs, V
Nieuwboer, A
Verheyden, G
Journal name Scientific Reports
Volume number 9
Article ID 19712
Start page 1
End page 9
Total pages 9
Publisher Nature Publishing Group
Place of publication London, Eng.
Publication date 2019
ISSN 2045-2322
Summary Corticospinal tract integrity after stroke has been widely investigated through the evaluation of fibres descending from the primary motor cortex. However, about half of the corticospinal tract is composed by sub-pathways descending from premotor and parietal areas, to which damage may play a more specific role in motor impairment and recovery, particularly post-stroke. Therefore, the main aim of this study was to investigate lesion load within corticospinal tract sub-pathways as predictors of upper limb motor impairment after stroke. Motor impairment (Fugl-Meyer Upper Extremity score) was evaluated in 27 participants at one week and six months after stroke, together with other clinical and demographic data. Neuroimaging data were obtained within the first week after stroke. Univariate regression analysis indicated that among all neural correlates, lesion load within premotor fibres explained the most variance in motor impairment at six months (R2 = 0.44, p < 0.001). Multivariable regression analysis resulted in three independent, significant variables explaining motor impairment at six months; Fugl-Meyer Upper Extremity score at one week, premotor dorsal fibre lesion load at one week, and age below or above 70 years (total R2 = 0.81; p < 0.001). Early examination of premotor dorsal fibre integrity may be a promising biomarker of upper limb motor impairment after stroke.
Language eng
DOI 10.1038/s41598-019-56334-w
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30152593

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.