Openly accessible

Multi-functional core-shell nanofibers for wound healing

Li, Zhen, Mei, S, Dong, Yajie, She, Fenghua, Li, P, Li, Y and Kong, Lingxue 2021, Multi-functional core-shell nanofibers for wound healing, Nanomaterials, vol. 11, no. 6, pp. 1-19, doi: 10.3390/nano11061546.

Attached Files
Name Description MIMEType Size Downloads

Title Multi-functional core-shell nanofibers for wound healing
Author(s) Li, Zhen
Mei, S
Dong, Yajie
She, FenghuaORCID iD for She, Fenghua orcid.org/0000-0001-8191-0820
Li, P
Li, Y
Kong, LingxueORCID iD for Kong, Lingxue orcid.org/0000-0001-6219-3897
Journal name Nanomaterials
Volume number 11
Issue number 6
Article ID 1546
Start page 1
End page 19
Total pages 19
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2021
ISSN 2079-4991
2079-4991
Keyword(s) co-axial centrifugal spinning
core-shell nanofiber
drug delivery
wound healing
Summary Core-shell nanofibers have great potential for bio-medical applications such as wound healing dressings where multiple drugs and growth factors are expected to be delivered at different healing phases. Compared to monoaxial nanofibers, core-shell nanofibers can control the drug release profile easier, providing sustainable and effective drugs and growth factors for wound healing. However, it is challenging to produce core-shell structured nanofibers with a high production rate at low energy consumption. Co-axial centrifugal spinning is an alternative method to address the above limitations to produce core-shell nanofibers effectively. In this study, a co-axial centrifugal spinning device was designed and assembled to produce core-shell nanofibers for controlling the release rate of ibuprofen and hEGF in inflammation and proliferation phases during the wound healing process. Core-shell structured nanofibers were confirmed by TEM. This work demonstrated that the co-axial centrifugal spinning is a high productivity process that can produce materials with a 3D environment mimicking natural tissue scaffold, and the specific drug can be loaded into different layers to control the drug release rate to improve the drug efficiency and promote wound healing.
Language eng
DOI 10.3390/nano11061546
Field of Research 0912 Materials Engineering
1007 Nanotechnology
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30152755

Document type: Journal Article
Collections: Institute for Frontier Materials
Open Access Collection
GTP Research
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 11 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Tue, 22 Jun 2021, 08:17:48 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.