Openly accessible

Xmrks the Spot: Fish Models for Investigating Epidermal Growth Factor Receptor Signaling in Cancer Research

Monroe, JD, Basheer, F and Gibert, Yann 2021, Xmrks the Spot: Fish Models for Investigating Epidermal Growth Factor Receptor Signaling in Cancer Research, Cells, vol. 10, no. 5, pp. 1-20, doi: 10.3390/cells10051132.

Attached Files
Name Description MIMEType Size Downloads

Title Xmrks the Spot: Fish Models for Investigating Epidermal Growth Factor Receptor Signaling in Cancer Research
Author(s) Monroe, JD
Basheer, F
Gibert, Yann
Journal name Cells
Volume number 10
Issue number 5
Article ID 1132
Start page 1
End page 20
Total pages 20
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2021
ISSN 2073-4409
2073-4409
Keyword(s) AUTOCRINE STIMULATION
cancer
Cell Biology
CELL-PROLIFERATION
drug discovery
epidermal growth factor receptor
EXTRACELLULAR DOMAIN
HEPATOCELLULAR-CARCINOMA
IN-VITRO
Life Sciences & Biomedicine
melanoma
NF-KAPPA-B
PROMOTES TUMOR-GROWTH
Science & Technology
signal transduction
TRANSCRIPTIONAL ACTIVATION
TYROSINE KINASE XMRK
Xiphophorus
XIPHOPHORUS MELANOMA
Xmrk
zebrafish
Summary Studies conducted in several fish species, e.g., Xiphophorus hellerii (green swordtail) and Xiphophorus maculatus (southern platyfish) crosses, Oryzias latipes (medaka), and Danio rerio (zebrafish), have identified an oncogenic role for the receptor tyrosine kinase, Xmrk, a gene product closely related to the human epidermal growth factor receptor (EGFR), which is associated with a wide variety of pathological conditions, including cancer. Comparative analyses of Xmrk and EGFR signal transduction in melanoma have shown that both utilize STAT5 signaling to regulate apoptosis and cell proliferation, PI3K to modulate apoptosis, FAK to control migration, and the Ras/Raf/MEK/MAPK pathway to regulate cell survival, proliferation, and differentiation. Further, Xmrk and EGFR may also modulate similar chemokine, extracellular matrix, oxidative stress, and microRNA signaling pathways in melanoma. In hepatocellular carcinoma (HCC), Xmrk and EGFR signaling utilize STAT5 to regulate cell proliferation, and Xmrk may signal through PI3K and FasR to modulate apoptosis. At the same time, both activate the Ras/Raf/MEK/MAPK pathway to regulate cell proliferation and E-cadherin signaling. Xmrk models of melanoma have shown that inhibitors of PI3K and MEK have an anti-cancer effect, and in HCC, that the steroidal drug, adrenosterone, can prevent metastasis and recover E-cadherin expression, suggesting that fish Xmrk models can exploit similarities with EGFR signal transduction to identify and study new chemotherapeutic drugs.
Language eng
DOI 10.3390/cells10051132
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30152895

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 9 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Fri, 25 Jun 2021, 08:52:52 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.