The Effect of Adjunctive Mangosteen Pericarp on Cognition in People With Schizophrenia: Secondary Analysis of a Randomized Controlled Trial Marx, W, Skvarc, David, Mohebbi, Mohammadreza, Walker, Adam, Meehan, A, Turner, Alyna, Baker, A, Dodd, Seetal, Cotton, SM, Scott, JG, Kavanagh, BE, Ashton, Melanie, Brown, E, McGrath, JJ, Berk, Michael and Dean, Olivia 2021, The Effect of Adjunctive Mangosteen Pericarp on Cognition in People With Schizophrenia: Secondary Analysis of a Randomized Controlled Trial, Frontiers in Psychiatry, vol. 12, pp. 1-8, doi: 10.3389/fpsyt.2021.626486. Attached Files Name Description MIMEType Size Downloads Title The Effect of Adjunctive Mangosteen Pericarp on Cognition in People With Schizophrenia: Secondary Analysis of a Randomized Controlled Trial Author(s) Marx, W Skvarc, David orcid.org/0000-0002-3334-4980 Mohebbi, Mohammadreza orcid.org/0000-0001-9713-7211 Walker, Adam orcid.org/0000-0002-5399-1245 Meehan, A Turner, Alyna orcid.org/0000-0001-7389-2546 Baker, A Dodd, Seetal orcid.org/0000-0002-7918-4636 Cotton, SM Scott, JG Kavanagh, BE Ashton, Melanie orcid.org/0000-0001-6832-4157 Brown, E McGrath, JJ Berk, Michael orcid.org/0000-0002-5554-6946 Dean, Olivia orcid.org/0000-0002-2776-3935 Journal name Frontiers in Psychiatry Volume number 12 Article ID 626486 Start page 1 End page 8 Total pages 8 Publisher Frontiers Media Place of publication Lausanne, Switzerland Publication date 2021-06 ISSN 1664-0640 1664-0640 Keyword(s) BIOAVAILABILITY cognition DISORDER IMPAIRMENT Life Sciences & Biomedicine Mangostana garcinia Linn. mangosteen mental disorders PANSS psychiatry schizoaffective disorder schizophrenia Science & Technology Summary Background: Cognitive impairment is prevalent and often highly burdensome in people with schizophrenia. The aim of this study was to investigate if mangosteen (Garcinia mangostana Linn.) pericarp extract may be an effective intervention to improve cognitive performance in this population.Methods: This was a secondary analysis of a larger randomized placebo-controlled trial that investigated a 24-weeks intervention of mangosteen pericarp extract supplementation in people diagnosed with schizophrenia. A subset of n = 114 participants with completed cognitive outcomes at follow up were included in this analysis. Using the Cogstate Brief Battery, the following cognitive outcomes were assessed: psychomotor function, attention, visual learning and memory (visual and working). Subgroup analyses investigated whether baseline clinical parameters (baseline cognitive functioning, illness severity and duration, depressive symptoms) moderated the relationship between mangosteen pericarp extract intervention and change in cognitive outcomes.Results: There were no significant between-group changes in any cognitive outcomes assessed. Subgroup analysis based on baseline cognition and clinical characteristics did not reveal any significant between-group difference in change.Conclusions: Mangosteen pericarp extract did not affect cognitive outcomes in people with schizophrenia. Further investigation regarding optimal dosing strategies for mangosteen interventions and the testing of additional cognitive domains may be warranted.Trial Registration:ANZCTR.org.au identifier: ACTRN12616000859482, registered 30 June 3 2016. Language eng DOI 10.3389/fpsyt.2021.626486 Field of Research 110999 Neurosciences not elsewhere classified 1103 Clinical Sciences 1117 Public Health and Health Services 1701 Psychology Socio Economic Objective 920410 Mental Health HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30153063 Document type: Journal Article Collections: Faculty of Health School of Psychology Open Access Collection Related Links Link Description Link to full-text (open access)   Connect to published version Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 05 Jul 2021, 08:21:45 EST Tue, 06 Jul 2021, 05:00:58 EST Tue, 06 Jul 2021, 08:19:30 EST Thu, 15 Jul 2021, 06:10:49 EST Sat, 17 Jul 2021, 02:30:34 EST Thu, 16 Sep 2021, 15:07:23 EST Thu, 16 Sep 2021, 15:59:44 EST Thu, 16 Sep 2021, 16:18:21 EST Sat, 25 Sep 2021, 00:36:02 EST Sat, 25 Dec 2021, 01:44:30 EST Filtered Full Citation counts:   Cited 1 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 111 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Mon, 05 Jul 2021, 08:21:45 EST