Openly accessible

The Effect of Adjunctive Mangosteen Pericarp on Cognition in People With Schizophrenia: Secondary Analysis of a Randomized Controlled Trial

Marx, W, Skvarc, David, Mohebbi, Mohammadreza, Walker, Adam, Meehan, A, Turner, Alyna, Baker, A, Dodd, Seetal, Cotton, SM, Scott, JG, Kavanagh, BE, Ashton, Melanie, Brown, E, McGrath, JJ, Berk, Michael and Dean, Olivia 2021, The Effect of Adjunctive Mangosteen Pericarp on Cognition in People With Schizophrenia: Secondary Analysis of a Randomized Controlled Trial, Frontiers in Psychiatry, vol. 12, pp. 1-8, doi: 10.3389/fpsyt.2021.626486.

Attached Files
Name Description MIMEType Size Downloads

Title The Effect of Adjunctive Mangosteen Pericarp on Cognition in People With Schizophrenia: Secondary Analysis of a Randomized Controlled Trial
Author(s) Marx, W
Skvarc, DavidORCID iD for Skvarc, David orcid.org/0000-0002-3334-4980
Mohebbi, MohammadrezaORCID iD for Mohebbi, Mohammadreza orcid.org/0000-0001-9713-7211
Walker, AdamORCID iD for Walker, Adam orcid.org/0000-0002-5399-1245
Meehan, A
Turner, AlynaORCID iD for Turner, Alyna orcid.org/0000-0001-7389-2546
Baker, A
Dodd, SeetalORCID iD for Dodd, Seetal orcid.org/0000-0002-7918-4636
Cotton, SM
Scott, JG
Kavanagh, BE
Ashton, MelanieORCID iD for Ashton, Melanie orcid.org/0000-0001-6832-4157
Brown, E
McGrath, JJ
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Dean, OliviaORCID iD for Dean, Olivia orcid.org/0000-0002-2776-3935
Journal name Frontiers in Psychiatry
Volume number 12
Article ID 626486
Start page 1
End page 8
Total pages 8
Publisher Frontiers Media
Place of publication Lausanne, Switzerland
Publication date 2021-06
ISSN 1664-0640
1664-0640
Keyword(s) BIOAVAILABILITY
cognition
DISORDER
IMPAIRMENT
Life Sciences & Biomedicine
Mangostana garcinia Linn.
mangosteen
mental disorders
PANSS
psychiatry
schizoaffective disorder
schizophrenia
Science & Technology
Summary Background: Cognitive impairment is prevalent and often highly burdensome in people with schizophrenia. The aim of this study was to investigate if mangosteen (Garcinia mangostana Linn.) pericarp extract may be an effective intervention to improve cognitive performance in this population.Methods: This was a secondary analysis of a larger randomized placebo-controlled trial that investigated a 24-weeks intervention of mangosteen pericarp extract supplementation in people diagnosed with schizophrenia. A subset of n = 114 participants with completed cognitive outcomes at follow up were included in this analysis. Using the Cogstate Brief Battery, the following cognitive outcomes were assessed: psychomotor function, attention, visual learning and memory (visual and working). Subgroup analyses investigated whether baseline clinical parameters (baseline cognitive functioning, illness severity and duration, depressive symptoms) moderated the relationship between mangosteen pericarp extract intervention and change in cognitive outcomes.Results: There were no significant between-group changes in any cognitive outcomes assessed. Subgroup analysis based on baseline cognition and clinical characteristics did not reveal any significant between-group difference in change.Conclusions: Mangosteen pericarp extract did not affect cognitive outcomes in people with schizophrenia. Further investigation regarding optimal dosing strategies for mangosteen interventions and the testing of additional cognitive domains may be warranted.Trial Registration:ANZCTR.org.au identifier: ACTRN12616000859482, registered 30 June 3 2016.
Language eng
DOI 10.3389/fpsyt.2021.626486
Field of Research 110999 Neurosciences not elsewhere classified
1103 Clinical Sciences
1117 Public Health and Health Services
1701 Psychology
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30153063

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
Open Access Collection
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 10 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Mon, 05 Jul 2021, 08:21:45 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.