Openly accessible

Effect of macronutrient composition on appetite hormone responses in adolescents with obesity

Nguo, K, Bonham, M P, Truby, H, Barber, E, Brown, J and Huggins, Catherine E. 2019, Effect of macronutrient composition on appetite hormone responses in adolescents with obesity, Nutrients, vol. 11, no. 2, pp. 1-14, doi: 10.3390/nu11020340.

Attached Files
Name Description MIMEType Size Downloads

Title Effect of macronutrient composition on appetite hormone responses in adolescents with obesity
Author(s) Nguo, K
Bonham, M P
Truby, H
Barber, E
Brown, J
Huggins, Catherine E.
Journal name Nutrients
Volume number 11
Issue number 2
Article ID 340
Start page 1
End page 14
Total pages 14
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2019
ISSN 2072-6643
2072-6643
Keyword(s) adolescent
appetite
CARBOHYDRATE
ENERGY-INTAKE
FOOD-INTAKE
ghrelin
GLP-1
GLUCAGON-LIKE PEPTIDE-1
Life Sciences & Biomedicine
MEAL RESPONSES
NORMAL-WEIGHT
Nutrition & Dietetics
obesity
OVERWEIGHT
PLASMA GHRELIN
PROTEIN
PUBERTAL CHANGES
Science & Technology
Summary Gut appetite hormone responses may be influenced by meal macronutrients and obesity. The primary aim of this study was to examine in adolescents with obesity and of healthy weight the effect of a high-protein and a high-carbohydrate meal on postprandial gut appetite hormones. A postprandial cross-over study with adolescents 11–19 years old was undertaken. Participants consumed, in random order, a high 79% carbohydrate (HCHO) and a high 55% protein (HP) meal. Ghrelin, glucagon-like peptide 1 (GLP-1), peptide YY (PYY), and self-reported appetite were assessed for four hours postprandial. Total energy intake from an ad libitum lunch and remaining 24 h was assessed. Eight adolescents with obesity (OB) and 12 with healthy weight (HW) participated. Compared with HW, OB adolescents displayed a smaller ghrelin iAUC (−25,896.5 ± 7943 pg/mL/4 h vs. −60,863.5 ± 13104 pg/mL/4 h) (p = 0.008) with no effect of meal (p > 0.05). The suppression of ghrelin relative to baseline was similar between OB and HW. Ghrelin suppression was greater following the HP vs. HCHO meal (effect of meal, p = 0.018). Glucose and insulin response were greater following HCHO vs. HP, with responses more marked in OB (time × weight × meal interaction, p = 0.003 and p = 0.018, respectively). There were no effects of weight or macronutrient on GLP-1 or PYY, appetite or subsequent energy intake. The present study demonstrates that dietary protein can modulate postprandial ghrelin responses; however, this did not translate to subsequent changes in subjective appetite or energy intake
Language eng
DOI 10.3390/nu11020340
Indigenous content off
Field of Research 0908 Food Sciences
1111 Nutrition and Dietetics
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30153172

Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 5 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 10 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Wed, 07 Jul 2021, 08:32:29 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.