Openly accessible

Repetitive transcranial magnetic stimulation (rTMS) in autism spectrum disorder: Protocol for a multicentre randomised controlled clinical trial

Enticott, Peter, Barlow, K, Guastella, AJ, Licari, MK, Rogasch, NC, Middeldorp, CM, Clark, SR, Vallence, AM, Boulton, KA, Hickie, IB, Whitehouse, AJO, Galletly, C, Alvares, GA, Fujiyama, H, Heussler, H, Craig, Jeffrey, Kirkovski, Melissa, Mills, NT, Rinehart, Nicole, Donaldson, Peter, Ford, Talitha, Caeyenberghs, Karen, Albein-Urios, Natalia, Bekkali, Soukayna and Fitzgerald, PB 2021, Repetitive transcranial magnetic stimulation (rTMS) in autism spectrum disorder: Protocol for a multicentre randomised controlled clinical trial, BMJ Open, vol. 11, pp. 1-9, doi: 10.1136/bmjopen-2020-046830.

Attached Files
Name Description MIMEType Size Downloads

Title Repetitive transcranial magnetic stimulation (rTMS) in autism spectrum disorder: Protocol for a multicentre randomised controlled clinical trial
Author(s) Enticott, PeterORCID iD for Enticott, Peter orcid.org/0000-0002-6638-951X
Barlow, K
Guastella, AJ
Licari, MK
Rogasch, NC
Middeldorp, CM
Clark, SR
Vallence, AM
Boulton, KA
Hickie, IB
Whitehouse, AJO
Galletly, C
Alvares, GA
Fujiyama, H
Heussler, H
Craig, JeffreyORCID iD for Craig, Jeffrey orcid.org/0000-0003-3979-7849
Kirkovski, MelissaORCID iD for Kirkovski, Melissa orcid.org/0000-0003-3395-8525
Mills, NT
Rinehart, NicoleORCID iD for Rinehart, Nicole orcid.org/0000-0001-6109-3958
Donaldson, PeterORCID iD for Donaldson, Peter orcid.org/0000-0001-7715-8891
Ford, TalithaORCID iD for Ford, Talitha orcid.org/0000-0001-5400-2659
Caeyenberghs, KarenORCID iD for Caeyenberghs, Karen orcid.org/0000-0001-7009-6843
Albein-Urios, NataliaORCID iD for Albein-Urios, Natalia orcid.org/0000-0001-7841-018X
Bekkali, Soukayna
Fitzgerald, PB
Journal name BMJ Open
Volume number 11
Article ID e046830
Start page 1
End page 9
Total pages 9
Publisher BMJ
Place of publication London, Eng.
Publication date 2021-07-07
ISSN 2044-6055
2044-6055
Keyword(s) child & adolescent psychiatry
CHILDREN
DEPRESSION
developmental neurology & neurodisability
DOUBLE-BLIND
General & Internal Medicine
Life Sciences & Biomedicine
Medicine, General & Internal
NETWORK
neurophysiology
paediatric neurology
Science & Technology
Summary IntroductionThere are no well-established biomedical treatments for the core symptoms of autism spectrum disorder (ASD). A small number of studies suggest that repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, may improve clinical and cognitive outcomes in ASD. We describe here the protocol for a funded multicentre randomised controlled clinical trial to investigate whether a course of rTMS to the right temporoparietal junction (rTPJ), which has demonstrated abnormal brain activation in ASD, can improve social communication in adolescents and young adults with ASD.Methods and analysisThis study will evaluate the safety and efficacy of a 4-week course of intermittent theta burst stimulation (iTBS, a variant of rTMS) in ASD. Participants meeting criteria for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition ASD (n=150, aged 14–40 years) will receive 20 sessions of either active iTBS (600 pulses) or sham iTBS (in which a sham coil mimics the sensation of iTBS, but no active stimulation is delivered) to the rTPJ. Participants will undergo a range of clinical, cognitive, epi/genetic, and neurophysiological assessments before and at multiple time points up to 6 months after iTBS. Safety will be assessed via a structured questionnaire and adverse event reporting. The study will be conducted from November 2020 to October 2024.Ethics and disseminationThe study was approved by the Human Research Ethics Committee of Monash Health (Melbourne, Australia) under Australia’s National Mutual Acceptance scheme. The trial will be conducted according to Good Clinical Practice, and findings will be written up for scholarly publication.Trial registration numberAustralian New Zealand Clinical Trials Registry (ACTRN12620000890932).
Language eng
DOI 10.1136/bmjopen-2020-046830
Field of Research 1103 Clinical Sciences
1117 Public Health and Health Services
1199 Other Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30153481

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
Open Access Collection
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 14 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Mon, 12 Jul 2021, 08:40:58 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.