Cognitive Profile and Relationship with Quality of Life and Psychosocial Functioning in Mood Disorders

Zazula, R, Mohebbi, Mohammadreza, Dodd, Seetal, Dean, Olivia, Berk, Michael, Vargas, HO and Nunes, SOV 2021, Cognitive Profile and Relationship with Quality of Life and Psychosocial Functioning in Mood Disorders, Archives of Clinical Neuropsychology, pp. 1-14, doi: 10.1093/arclin/acab054.

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Title Cognitive Profile and Relationship with Quality of Life and Psychosocial Functioning in Mood Disorders
Author(s) Zazula, R
Mohebbi, MohammadrezaORCID iD for Mohebbi, Mohammadreza
Dodd, SeetalORCID iD for Dodd, Seetal
Dean, OliviaORCID iD for Dean, Olivia
Berk, MichaelORCID iD for Berk, Michael
Vargas, HO
Nunes, SOV
Journal name Archives of Clinical Neuropsychology
Start page 1
End page 14
Total pages 14
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2021-07-13
ISSN 0887-6177
Keyword(s) Bipolar disorder
Cognitive functioning
Cognitive impairment
Quality of life
Summary Abstract Background Comparisons between healthy controls (HCs) and individuals with mood disorders have shown more cognitive dysfunction among the latter group, in particular in bipolar disorder (BD). This study aimed to characterize the pattern of cognitive function of BD and major depressive disorder (MDD) and compare them to HC using the (CogState Research Battery) CSRB™. Method Participants were tested, comprising the following domains: processing speed, attention, working memory, visual memory, executive functions, and verbal memory. Quality of life and functionality were also assessed. Multiple linear regression models were performed to examine the effect of demographic characteristics and functionality on cognitive outcomes separately for BD and MDD. Results Ninety individuals participated in the study, of which 32 had BD, 30 had MDD, and 28 were HC. Differences were found between both BD and MDD and HC for the composite cognitive score, with significant differences between BD and HC (Diff = −5.5, 95% CI = [−9.5, −1.5], p = 0.005), and MDD and HC (Diff = −4.6, 95% CI = [−8.6, −0.5], p = 0.025). There were overall significant differences in five cognitive domains: processing speed (p = 0.001 and p = 0.004), attention (p = 0.002), working memory (p = 0.02), visual memory (p = 0.021), and verbal memory (p = 0.007). BD also presented worse performance than both MDD and HC, and MDD presented better performance than BD but worse than HC in quality of life and functionality. Multiple linear regression models were significative for education (p < 0.001) and age (p = 0.004) for BD and education (p < 0.001) for MDD. Conclusion In general, cognition is more affected in BD than MDD, which could be associated with functional and quality of life impairment.
Notes In Press
Language eng
DOI 10.1093/arclin/acab054
Indigenous content off
Field of Research 110999 Neurosciences not elsewhere classified
1109 Neurosciences
1701 Psychology
1702 Cognitive Sciences
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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