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Postpartum Circulating Cell-Free Insulin DNA Levels Are Higher in Women with Previous Gestational Diabetes Mellitus Who Develop Type 2 Diabetes in Later Life

Lappas, M, Georgiou, HM, Willcox, Jane, Permezel, M, Shub, A, Maynard, C-L, Joglekar, MV and Hardikar, AA 2019, Postpartum Circulating Cell-Free Insulin DNA Levels Are Higher in Women with Previous Gestational Diabetes Mellitus Who Develop Type 2 Diabetes in Later Life, Journal of Diabetes Research, vol. 2019, pp. 1-5, doi: 10.1155/2019/3264184.

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Title Postpartum Circulating Cell-Free Insulin DNA Levels Are Higher in Women with Previous Gestational Diabetes Mellitus Who Develop Type 2 Diabetes in Later Life
Author(s) Lappas, M
Georgiou, HM
Willcox, JaneORCID iD for Willcox, Jane orcid.org/0000-0002-6306-5333
Permezel, M
Shub, A
Maynard, C-L
Joglekar, MV
Hardikar, AA
Journal name Journal of Diabetes Research
Volume number 2019
Article ID 3264184
Start page 1
End page 5
Total pages 5
Publisher Hindawi Publishing Corporation
Place of publication New York, N.Y.
Publication date 2019
ISSN 2314-6745
2314-6753
Summary Background. Women with previous gestational diabetes mellitus (GDM) have evidence of postpartum β-cell dysfunction, which increases their risk of developing type 2 diabetes (T2DM) later in life. Elevated levels of circulating cell-free preproinsulin (INS) DNA correlate with dying β-cells in both mice and humans. The aim of this study was to determine if cell-free circulating INS DNA levels are higher in women with previous GDM who develop T2DM. Methods. We used droplet digital (dd) PCR to measure the levels of cell-free circulating methylated and unmethylated INS DNA in plasma from 97 women with normal glucose tolerance (NGT), 12 weeks following an index GDM pregnancy. Women were assessed for up to 10 years for the development of T2DM. Results. In the follow-up period, 22% of women developed T2DM. Compared with NGT women, total cell-free INS DNA levels were significantly higher in women who developed T2DM (P=0.02). There was no difference in cell-free circulating unmethylated and methylated INS DNA levels between NGT women and women who developed T2DM (P=0.09 and P=0.07, respectively). Conclusions. In women with a previous index GDM pregnancy, postpartum levels of cell-free circulating INS DNA are significantly higher in those women who later developed T2DM.
Language eng
DOI 10.1155/2019/3264184
Field of Research 1116 Medical Physiology
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30153673

Document type: Journal Article
Collections: Faculty of Health
School of Nursing and Midwifery
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.