The association between migrant status and transition in an ultra-high risk for psychosis population

O’Donoghue, B, Geros, H, Sizer, H, Addington, J, Amminger, GP, Beaden, CE, Cadenhead, KS, Cannon, TD, Cornblatt, BA, Berger, GE, Chen, EYH, de Haan, L, Hartmann, JA, Hickie, IB, Ising, HK, Lavoie, S, Lin, A, Markulev, C, Mathalon, DH, McGlashan, TH, Mifsud, NG, Mossaheb, N, Nieman, DH, Nordentoft, M, Perkins, DO, Riecher-Rössler, A, Schäfer, MR, Schlögelhofer, M, Seidman, LJ, Smesny, S, Thompson, A, Tsuang, MT, van der Gaag, M, Verma, S, Walker, EF, Wood, SJ, Woods, SW, Yuen, HP, Yung, Alison, McGorry, PD and Nelson, B 2021, The association between migrant status and transition in an ultra-high risk for psychosis population, Social Psychiatry and Psychiatric Epidemiology, vol. 56, no. 6, pp. 943-952, doi: 10.1007/s00127-020-02012-6.

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Title The association between migrant status and transition in an ultra-high risk for psychosis population
Author(s) O’Donoghue, B
Geros, H
Sizer, H
Addington, J
Amminger, GP
Beaden, CE
Cadenhead, KS
Cannon, TD
Cornblatt, BA
Berger, GE
Chen, EYH
de Haan, L
Hartmann, JA
Hickie, IB
Ising, HK
Lavoie, S
Lin, A
Markulev, C
Mathalon, DH
McGlashan, TH
Mifsud, NG
Mossaheb, N
Nieman, DH
Nordentoft, M
Perkins, DO
Riecher-Rössler, A
Schäfer, MR
Schlögelhofer, M
Seidman, LJ
Smesny, S
Thompson, A
Tsuang, MT
van der Gaag, M
Verma, S
Walker, EF
Wood, SJ
Woods, SW
Yuen, HP
Yung, Alison
McGorry, PD
Nelson, B
Journal name Social Psychiatry and Psychiatric Epidemiology
Volume number 56
Issue number 6
Start page 943
End page 952
Total pages 10
Publisher Springer
Place of publication Berlin, Germany
Publication date 2021
ISSN 0933-7954
Keyword(s) Migrants
Psychotic disorders
Ultra-high risk for psychosis
Summary Purpose: Migrant status is one of the most replicated and robust risk factors for developing a psychotic disorder. This study aimed to determine whether migrant status in people identified as Ultra-High Risk for Psychosis (UHR) was associated with risk of transitioning to a full-threshold psychotic disorder. Methods: Hazard ratios for the risk of transition were calculated from five large UHR cohorts (n = 2166) and were used to conduct a meta-analysis using the generic inverse-variance method using a random-effects model. Results: 2166 UHR young people, with a mean age of 19.1 years (SD ± 4.5) were included, of whom 221 (10.7%) were first-generation migrants. A total of 357 young people transitioned to psychosis over a median follow-up time of 417 days (I.Q.R.147–756 days), representing 17.0% of the cohort. The risk of transition to a full-threshold disorder was not increased for first-generation migrants, (HR = 1.08, 95% CI 0.62–1.89); however, there was a high level of heterogeneity between studies The hazard ratio for second-generation migrants to transition to a full-threshold psychotic disorder compared to the remainder of the native-born population was 1.03 (95% CI 0.70–1.51). Conclusions: This meta-analysis did not find a statistically significant association between migrant status and an increased risk for transition to a full-threshold psychotic disorder; however, several methodological issues could explain this finding. Further research should focus on examining the risk of specific migrant groups and also ensuring that migrant populations are adequately represented within UHR clinics.
Language eng
DOI 10.1007/s00127-020-02012-6
Field of Research 1103 Clinical Sciences
1701 Psychology
1702 Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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