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The Role of Mitochondria in Mood Disorders: From Physiology to Pathophysiology and to Treatment

Giménez-Palomo, A, Dodd, Seetal, Anmella, G, Carvalho, AF, Scaini, G, Quevedo, J, Pacchiarotti, I, Vieta, E and Berk, Michael 2021, The Role of Mitochondria in Mood Disorders: From Physiology to Pathophysiology and to Treatment, Frontiers in Psychiatry, vol. 12, pp. 1-26, doi: 10.3389/fpsyt.2021.546801.

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Title The Role of Mitochondria in Mood Disorders: From Physiology to Pathophysiology and to Treatment
Author(s) Giménez-Palomo, A
Dodd, SeetalORCID iD for Dodd, Seetal orcid.org/0000-0002-7918-4636
Anmella, G
Carvalho, AF
Scaini, G
Quevedo, J
Pacchiarotti, I
Vieta, E
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Journal name Frontiers in Psychiatry
Volume number 12
Article ID 546801
Start page 1
End page 26
Total pages 26
Publisher Frontiers Media
Place of publication Lausanne, Switzerland
Publication date 2021
ISSN 1664-0640
1664-0640
Keyword(s) ACETYL-L-CARNITINE
ALPHA-LIPOIC ACID
bipolar disorder
COMPLEX-I ACTIVITY
GLUCOCORTICOID-RECEPTOR PHOSPHORYLATION
INDUCED OXIDATIVE STRESS
Life Sciences & Biomedicine
major depressive disorder
mitochondrial dysfunction
mood disorders
novel therapies
POLYUNSATURATED FATTY-ACIDS
POSTMORTEM FRONTAL-CORTEX
POTENTIAL PERIPHERAL MARKER
Psychiatry
Science & Technology
SEROTONIN REUPTAKE INHIBITORS
Summary Mitochondria are cellular organelles involved in several biological processes, especially in energy production. Several studies have found a relationship between mitochondrial dysfunction and mood disorders, such as major depressive disorder and bipolar disorder. Impairments in energy production are found in these disorders together with higher levels of oxidative stress. Recently, many agents capable of enhancing antioxidant defenses or mitochondrial functioning have been studied for the treatment of mood disorders as adjuvant therapy to current pharmacological treatments. A better knowledge of mitochondrial physiology and pathophysiology might allow the identification of new therapeutic targets and the development and study of novel effective therapies to treat these specific mitochondrial impairments. This could be especially beneficial for treatment-resistant patients. In this article, we provide a focused narrative review of the currently available evidence supporting the involvement of mitochondrial dysfunction in mood disorders, the effects of current therapies on mitochondrial functions, and novel targeted therapies acting on mitochondrial pathways that might be useful for the treatment of mood disorders.
Language eng
DOI 10.3389/fpsyt.2021.546801
Field of Research 1103 Clinical Sciences
1117 Public Health and Health Services
1701 Psychology
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30153969

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.