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Targeting the Host Response: Can We Manipulate Extracellular Matrix Metalloproteinase Activity to Improve Influenza Virus Infection Outcomes?

Pedrina, J and Stambas, John 2021, Targeting the Host Response: Can We Manipulate Extracellular Matrix Metalloproteinase Activity to Improve Influenza Virus Infection Outcomes?, Frontiers in Molecular Biosciences, vol. 8, pp. 1-8, doi: 10.3389/fmolb.2021.703456.

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Title Targeting the Host Response: Can We Manipulate Extracellular Matrix Metalloproteinase Activity to Improve Influenza Virus Infection Outcomes?
Author(s) Pedrina, J
Stambas, JohnORCID iD for Stambas, John orcid.org/0000-0002-5690-2551
Journal name Frontiers in Molecular Biosciences
Volume number 8
Article ID 703456
Start page 1
End page 8
Total pages 8
Publisher Frontiers Media
Place of publication Lausanne, Switzerland
Publication date 2021
ISSN 2296-889X
2296-889X
Keyword(s) ADAMTS PROTEASES
ANTIBODY
Biochemistry & Molecular Biology
COVID-19
EPIDEMIOLOGY
extracellular matrix
immunity
influenza
Life Sciences & Biomedicine
metalloproteinases
OSTEOARTHRITIS
PHARMACODYNAMICS
PHARMACOKINETICS
RESISTANCE
Science & Technology
therapeutics
VACCINES
VENTILATION
Summary Each year, hundreds of thousands of individuals succumb to influenza virus infection and its associated complications. Several preventative and therapeutic options may be applied in order to preserve life. These traditional approaches include administration of seasonal influenza vaccines, pharmacological interventions in the form of antiviral drug therapy and supportive clinical approaches including mechanical ventilation and extracorporeal membrane oxygenation. While these measures have shown varying degrees of success, antiviral therapies and vaccination are constrained due to ongoing antigenic drift. Moreover, clinical approaches can also be associated with complications and drawbacks. These factors have led to the exploration and development of more sophisticated and nuanced therapeutic approaches involving host proteins. Advances in immunotherapy in the cancer field or administration of steroids following virus infection have highlighted the therapeutic potential of targeting host immune responses. We have now reached a point where we can consider the contribution of other “non-traditional” host components such as the extracellular matrix in immunity. Herein, we will review current, established therapeutic interventions and consider novel therapeutic approaches involving the extracellular matrix.
Language eng
DOI 10.3389/fmolb.2021.703456
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30154236

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.