Flow rate-insensitive microparticle separation and filtration using a microchannel with arc-shaped groove arrays

Zhao, Q, Yuan, Dan, Yan, S, Zhang, J, Du, H, Alici, G and Li, W, Flow rate-insensitive microparticle separation and filtration using a microchannel with arc-shaped groove arrays, ICMFLOC 2016 : Proceedings of the International Conference of Microfluidics and Nanofluidics and Lab-on-a-Chip and Microfluidics and Nanofluidics, pp. 1-11, doi: 10.1007/s10404-017-1890-y.

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Title Flow rate-insensitive microparticle separation and filtration using a microchannel with arc-shaped groove arrays
Author(s) Zhao, Q
Yuan, Dan
Yan, S
Zhang, J
Du, H
Alici, G
Li, W
Journal name ICMFLOC 2016 : Proceedings of the International Conference of Microfluidics and Nanofluidics and Lab-on-a-Chip
Microfluidics and Nanofluidics
Start page 1
End page 11
Total pages 11
Publisher Springer
Place of publication Dalian, China
Berlin, Germany
ISSN 1613-4982
1613-4990
Keyword(s) Science & Technology
Technology
Physical Sciences
Nanoscience & Nanotechnology
Instruments & Instrumentation
Physics, Fluids & Plasmas
Science & Technology - Other Topics
Physics
CIRCULATING TUMOR-CELLS
DETERMINISTIC LATERAL DISPLACEMENT
CONTINUOUS PARTICLE SEPARATION
POISEUILLE FLOW
MICROFLUIDIC CHANNEL
BLOOD
SHEATHLESS
Summary Inertial microfluidics can separate microparticles in a continuous and high-throughput manner, and is very promising for a wide range of industrial, biomedical and clinical applications. However, most of the proposed inertial microfluidic devices only work effectively at a limited and narrow flow rate range because the performance of inertial particle focusing and separation is normally very sensitive to the flow rate (Reynolds number). In this work, an innovative particle separation method is proposed and developed by taking advantage of the secondary flow and particle inertial lift force in a straight channel (AR = 0.2) with arc-shaped groove arrays patterned on the channel top surface. Through the simulation results achieved, it can be found that a secondary flow is induced within the cross section of the microchannel and guides different-size particles to the corresponding equilibrium positions. On the other hand, the effects of the particle size, flow rate and particle concentration on particle focusing and separation quality were experimentally investigated. In the experiments, the performance of particle focusing, however, was found relatively insensitive to the variation of flow rate. According to this, a separation of 4.8 and 13 µm particle suspensions was designed and successfully achieved in the proposed microchannel, and the results show that a qualified particle separation can be achieved at a wide range of flow rate. This flow rate-insensitive microfluidic separation (filtration) method is able to potentially serve as a reliable biosample preparation processing step for downstream bioassays.
Language eng
DOI 10.1007/s10404-017-1890-y
Field of Research 0913 Mechanical Engineering
0915 Interdisciplinary Engineering
1007 Nanotechnology
HERDC Research category E1.1 Full written paper - refereed
Persistent URL http://hdl.handle.net/10536/DRO/DU:30154475

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