High throughput cell-free extraction of plasma by an integrated microfluidic device combining inertial microfluidics and membrane

Zhang, J, Yan, S, Yuan, Dan, Alici, G, Nguyen, NT and Li, W 2016, High throughput cell-free extraction of plasma by an integrated microfluidic device combining inertial microfluidics and membrane, in MNHMT 2016 : Proceedings of the 5th International Conference on Micro/Nanoscale Heat and Mass Transfer, American Society of Mechanical Engineers, New York, N.Y., pp. 1-6, doi: 10.1115/MNHMT2016-6717.

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Title High throughput cell-free extraction of plasma by an integrated microfluidic device combining inertial microfluidics and membrane
Author(s) Zhang, J
Yan, S
Yuan, Dan
Alici, G
Nguyen, NT
Li, W
Conference name Micro/Nanoscale Heat and Mass Transfer. Conference (2016 : 5th : Singapore)
Conference location Singapore
Conference dates 2016/01/04 - 2016/01/06
Title of proceedings MNHMT 2016 : Proceedings of the 5th International Conference on Micro/Nanoscale Heat and Mass Transfer
Publication date 2016
Start page 1
End page 6
Total pages 6
Publisher American Society of Mechanical Engineers
Place of publication New York, N.Y.
Summary Plasma is a host of various analytes such as proteins, metabolites, circulating nucleic acids (CNAs), pathogens. The key process of plasma extraction is to eliminate the contamination from blood cells. Conventional methods, such as centrifugation and membrane filtration, are generally lab-intensive, time consuming and even dangerous. In this study, we report an integrated microfluidic device that combines inertial microfluidics and membrane filter. The integrated microfluidic device was evaluated by the diluted (x1/10, x1/20) whole blood, and the quality of the extracted blood plasma was tested. It was found that quality of extracted blood plasma from integrated device was equivalent to that obtained by the centrifugation. This study demonstrates a significant progress towards the practical application of inertial microfluidics with membrane filter for high-throughput and high efficient blood plasma extraction.
ISBN 9780791849651
Language eng
DOI 10.1115/MNHMT2016-6717
HERDC Research category E1.1 Full written paper - refereed
Persistent URL http://hdl.handle.net/10536/DRO/DU:30154525

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