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Immune Microenvironment Landscape in CNS Tumors and Role in Responses to Immunotherapy

Najem, H, Khasraw, Mustafa and Heimberger, AB 2021, Immune Microenvironment Landscape in CNS Tumors and Role in Responses to Immunotherapy, Cells, vol. 10, no. 8, pp. 1-17, doi: 10.3390/cells10082032.

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Title Immune Microenvironment Landscape in CNS Tumors and Role in Responses to Immunotherapy
Author(s) Najem, H
Khasraw, MustafaORCID iD for Khasraw, Mustafa orcid.org/0000-0003-3249-9849
Heimberger, AB
Journal name Cells
Volume number 10
Issue number 8
Article ID 2032
Start page 1
End page 17
Total pages 17
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2021-08
ISSN 2073-4409
2073-4409
Keyword(s) CNS metastasis
glioma
immune checkpoints
immune composition
immune therapy
T cells
tumor associated macrophages/microglia
tumor microenvironment
Summary Despite the important evolution of immunotherapeutic agents, brain tumors remain, in general, refractory to immune therapeutics. Recent discoveries have revealed that the glioma microenvironment includes a wide variety of immune cells in various states that play an important role in the process of tumorigenesis. Anti-tumor immune activity may be occurring or induced in immunogenic hot spots or at the invasive edge of central nervous system (CNS) tumors. Understanding the complex heterogeneity of the immune microenvironment in gliomas will likely be the key to unlocking the full potential of immunotherapeutic strategies. An essential consideration will be the induction of immunological effector responses in the setting of the numerous aspects of immunosuppression and evasion. As such, immune therapeutic combinations are a fundamental objective for clinical studies in gliomas. Through immune profiling conducted on immune competent murine models of glioma and ex vivo human glioma tissue, we will discuss how the frequency, distribution of immune cells within the microenvironment, and immune modulatory processes, may be therapeutically modulated to lead to clinical benefits.
Language eng
DOI 10.3390/cells10082032
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30154538

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.