Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth Everson, TM, Vives-Usano, M, Seyve, E, Cardenas, A, Lacasaña, M, Craig, Jeffrey, Lesseur, C, Baker, ER, Fernandez-Jimenez, N, Heude, B, Perron, P, Gónzalez-Alzaga, B, Halliday, J, Deyssenroth, MA, Karagas, MR, Íñiguez, C, Bouchard, L, Carmona-Sáez, P, Loke, YJ, Hao, K, Belmonte, T, Charles, MA, Martorell-Marugán, J, Muggli, E, Chen, J, Fernández, MF, Tost, J, Gómez-Martín, A, London, SJ, Sunyer, J, Marsit, CJ, Lepeule, J, Hivert, MF and Bustamante, M 2021, Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth, Nature Communications, vol. 12, no. 1, pp. 1-13, doi: 10.1038/s41467-021-24558-y. Attached Files Name Description MIMEType Size Downloads Title Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth Author(s) Everson, TM Vives-Usano, M Seyve, E Cardenas, A Lacasaña, M Craig, Jeffrey orcid.org/0000-0003-3979-7849 Lesseur, C Baker, ER Fernandez-Jimenez, N Heude, B Perron, P Gónzalez-Alzaga, B Halliday, J Deyssenroth, MA Karagas, MR Íñiguez, C Bouchard, L Carmona-Sáez, P Loke, YJ Hao, K Belmonte, T Charles, MA Martorell-Marugán, J Muggli, E Chen, J Fernández, MF Tost, J Gómez-Martín, A London, SJ Sunyer, J Marsit, CJ Lepeule, J Hivert, MF Bustamante, M Journal name Nature Communications Volume number 12 Issue number 1 Article ID ARTN 5095 Start page 1 End page 13 Total pages 13 Publisher Springer Nature Place of publication Berlin, Germany Publication date 2021-12 ISSN 2041-1723 2041-1723 Keyword(s) Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics BIRTH-WEIGHT GENE-EXPRESSION FACTOR RECEPTOR COHORT PROFILE TROPHOBLAST NEWBORNS ASSOCIATIONS EXPOSURE HYPOXIA LENGTH Summary AbstractMaternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. Here we present a meta-analysis of the associations between MSDP and placental DNA methylation (DNAm) and between DNAm and birth outcomes within the Pregnancy And Childhood Epigenetics (PACE) consortium (N = 1700, 344 with MSDP). We identify 443 CpGs that are associated with MSDP, of which 142 associated with birth outcomes, 40 associated with gene expression, and 13 CpGs are associated with all three. Only two CpGs have consistent associations from a prior meta-analysis of cord blood DNAm, demonstrating substantial tissue-specific responses to MSDP. The placental MSDP-associated CpGs are enriched for environmental response genes, growth-factor signaling, and inflammation, which play important roles in placental function. We demonstrate links between placental DNAm, MSDP and poor birth outcomes, which may better inform the mechanisms through which MSDP impacts placental function and fetal growth. Language eng DOI 10.1038/s41467-021-24558-y HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30155331 Document type: Journal Article Collections: Faculty of Health Open Access Collection Related Links Link Description Link to full-text (open access)   Connect to Elements publication management system Go to link with your DU access privileges   Link Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 13 Sep 2021, 08:16:55 EST Mon, 13 Sep 2021, 08:44:57 EST Mon, 27 Jun 2022, 09:58:03 EST Mon, 27 Jun 2022, 12:45:06 EST Mon, 27 Jun 2022, 14:36:03 EST Mon, 27 Jun 2022, 14:59:23 EST Tue, 05 Jul 2022, 16:15:55 EST Tue, 19 Jul 2022, 10:53:58 EST Thu, 28 Jul 2022, 12:36:03 EST Filtered Full Citation counts:   Cited 7 times in TR Web of Science Cited 8 times in Scopus Search Google Scholar Access Statistics: 14 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Mon, 13 Sep 2021, 08:16:55 EST