The effects of surgery on plasma/serum vitamin C concentrations: A systematic review and meta-analysis Travica, Nikolaj, Ried, K, Hudson, I, Scholey, A, Pipingas, A and Sali, A 2022, The effects of surgery on plasma/serum vitamin C concentrations: A systematic review and meta-analysis, British Journal of Nutrition, vol. 127, no. 2, pp. 233-247, doi: 10.1017/S0007114520004353. Attached Files Name Description MIMEType Size Downloads Title The effects of surgery on plasma/serum vitamin C concentrations: A systematic review and meta-analysis Author(s) Travica, Nikolaj Ried, K Hudson, I Scholey, A Pipingas, A Sali, A Journal name British Journal of Nutrition Volume number 127 Issue number 2 Start page 233 End page 247 Total pages 15 Publisher Cambridge University Press (CUP) Place of publication England Publication date 2022-01-28 ISSN 0007-1145 1475-2662 Keyword(s) Ascorbate Depletion Surgery Trauma Vitamin C Summary AbstractVitamin C (ascorbic acid) is a water-soluble vitamin with an array of biological functions. A number of proposed factors contribute to the vitamin’s plasma bioavailability and ability to exert optimal functionality. The aim of this review was to systematically assess plasma vitamin C levels post-surgery compared with pre-surgery/the magnitude and time frame of potential changes in concentration. We searched the PUBMED, SCOPUS, SciSearch and the Cochrane Library databases between 1970 and April 2020 for relevant research papers. Prospective studies, control groups and true placebo groups derived from controlled trials that reported means and standard deviations of plasma vitamin C concentrations pre- and postoperatively were included into the meta-analysis. Data were grouped into short-term (≤7 d) and long-term (>7 d) postoperative follow-up. Twenty-three of thirty-one studies involving 642 patients included in the systematic review were suitable for meta-analysis. Pooled data from the meta-analysis revealed a mean depletion of plasma vitamin C concentration of −17·99 µmol/l (39 % depletion) (CI −22·81, −13·17) (trial arms = 25, n 565, P < 0·001) during the first postoperative week and −18·80 µmol/l (21 % depletion) (CI −25·04, −12·56) (trial arms = 6, n 166, P < 0·001) 2–3 months postoperatively. Subgroup analyses revealed that these depletions occurred following different types of surgery; however, high heterogeneity was observed amongst trials assessing concentration change during the first postoperative week. Overall, our results warrant larger, long-term investigations of changes in postoperative plasma vitamin C concentrations and their potential effects on clinical symptomology. Language en DOI 10.1017/S0007114520004353 Field of Research 0702 Animal Production 0908 Food Sciences 1111 Nutrition and Dietetics HERDC Research category C1 Refereed article in a scholarly journal Persistent URL http://hdl.handle.net/10536/DRO/DU:30155989 Document type: Journal Article Collections: Faculty of Health School of Psychology Related Links Link Description Connect to published version Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 27 Sep 2021, 12:46:27 EST Mon, 27 Sep 2021, 18:42:40 EST Mon, 27 Sep 2021, 18:47:23 EST Fri, 12 Nov 2021, 05:04:10 EST Mon, 06 Dec 2021, 09:31:36 EST Mon, 06 Dec 2021, 15:40:22 EST Mon, 06 Dec 2021, 15:44:32 EST Mon, 06 Dec 2021, 15:49:28 EST Tue, 21 Dec 2021, 00:36:25 EST Thu, 17 Feb 2022, 16:36:48 EST Wed, 23 Mar 2022, 13:10:34 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 4 times in Scopus Search Google Scholar Access Statistics: 49 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Mon, 27 Sep 2021, 12:46:27 EST