Nasal High Flow in Room Air for Hypoxemic Bronchiolitis Infants Franklin, D, Babl, FE, Gibbons, K, Pham, TMT, Hasan, N, Schlapbach, LJ, Oakley, E, Craig, S, Furyk, Jeremy, Neutze, J, Moloney, S, Gavranich, J, Shirkhedkar, P, Kapoor, V, Grew, S, Fraser, JF, Dalziel, S and Schibler, A 2019, Nasal High Flow in Room Air for Hypoxemic Bronchiolitis Infants, Frontiers, vol. 7, pp. 1-11, doi: 10.3389/fped.2019.00426. Attached Files Name Description MIMEType Size Downloads Title Nasal High Flow in Room Air for Hypoxemic Bronchiolitis Infants Author(s) Franklin, D Babl, FE Gibbons, K Pham, TMT Hasan, N Schlapbach, LJ Oakley, E Craig, S Furyk, Jeremy orcid.org/0000-0002-9503-0928 Neutze, J Moloney, S Gavranich, J Shirkhedkar, P Kapoor, V Grew, S Fraser, JF Dalziel, S Schibler, A Journal name Frontiers Volume number 7 Article ID 426 Start page 1 End page 11 Total pages 11 Publisher Frontiers Publication date 2019-10 ISSN 2296-2360 Summary Background: Bronchiolitis is the most common reason for hospital admission in infants, with one third requiring oxygen therapy due to hypoxemia. It is unknown what proportion of hypoxemic infants with bronchiolitis can be managed with nasal high-flow in room air and their resulting outcomes. Objectives and Settings: To assess the effect of nasal high-flow in room air in a subgroup of infants with bronchiolitis allocated to high-flow therapy in a recent multicenter randomized controlled trial. Patients and Interventions: Infants allocated to the high-flow arm of the trial were initially treated with room air high-flow if saturations were ≥85%. Subsequently, if oxygen saturations did not increase to ≥92%, oxygen was added and FiO2 was titrated to increase the oxygen saturations. In this planned sub-study, infants treated during their entire hospital stay with high-flow room air only were compared to infants receiving either standard-oxygen or high-flow with oxygen. Baseline characteristics, hospital length of stay and length of oxygen therapy were compared. Findings: In the per protocol analysis 64 (10%) of 630 infants commenced on high-flow room air remained in room air only during the entire stay in hospital. These infants on high-flow room air were on average older and presented with moderate hypoxemia at presentation to hospital. Their length of respiratory support and length of stay was also significantly shorter. No pre-enrolment factors could be identified in a multivariable analysis. Conclusions: In a small sub-group of hypoxemic infants with bronchiolitis hypoxemia can be reversed with the application of high-flow in room air only Language eng DOI 10.3389/fped.2019.00426 Field of Research 1114 Paediatrics and Reproductive Medicine 1199 Other Medical and Health Sciences HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30156151 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Link to full-text (open access)   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Tue, 28 Sep 2021, 12:59:33 EST Tue, 28 Sep 2021, 17:19:04 EST Fri, 12 Nov 2021, 05:05:26 EST Fri, 26 Nov 2021, 14:37:41 EST Fri, 26 Nov 2021, 15:05:47 EST Fri, 26 Nov 2021, 15:29:52 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 1 times in Scopus Search Google Scholar Access Statistics: 80 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Tue, 28 Sep 2021, 12:59:33 EST