The underappreciated role of epithelial mesenchymal transition in chronic obstructive pulmonary disease and its strong link to lung cancer Mahmood, Malik Quasir, Shukla, SD, Ward, C and Walters, EH 2021, The underappreciated role of epithelial mesenchymal transition in chronic obstructive pulmonary disease and its strong link to lung cancer, Biomolecules, vol. 11, no. 9, pp. 1-15, doi: 10.3390/biom11091394. Attached Files Name Description MIMEType Size Downloads Title The underappreciated role of epithelial mesenchymal transition in chronic obstructive pulmonary disease and its strong link to lung cancer Author(s) Mahmood, Malik Quasir orcid.org/0000-0003-1333-7940 Shukla, SD Ward, C Walters, EH Journal name Biomolecules Volume number 11 Issue number 9 Article ID 1394 Start page 1 End page 15 Total pages 15 Publisher MDPI Place of publication Basel, Switzerland Publication date 2021 ISSN 2218-273X 2218-273X Keyword(s) Biochemistry & Molecular Biology chronic obstructive pulmonary disease EMT epithelial-mesenchymal transition GENE-EXPRESSION Life Sciences & Biomedicine lung cancer METASTASIS MOLECULAR-MECHANISMS NF-KAPPA-B PLASTICITY PROSTATE-CANCER RENAL FIBROSIS Science & Technology STEM-CELLS TGF-BETA therapy Summary The World Health Organisation reported COPD to be the third leading cause of death globally in 2019, and in 2020, the most common cause of cancer death was lung cancer; when these linked conditions are added together they come near the top of the leading causes of mortality. The cell-biological program termed epithelial-to-mesenchymal transition (EMT) plays an important role in organ development, fibrosis and cancer progression. Over the past decade there has emerged a substantial literature that also links EMT specifically to the pathophysiology of chronic obstructive pulmonary disease (COPD) as primarily an airway fibrosis disease; COPD is a recognised strong independent risk factor for the development of lung cancer, over and above the risks associated with smoking. In this review, our primary focus is to highlight these linkages and alert both the COPD and lung cancer fields to these complex interactions. We emphasise the need for inter-disciplinary attention and research focused on the likely crucial roles of EMT (and potential for its inhibition) with recognition of its strategic place mechanistically in both COPD and lung cancer. As part of this we discuss the future potential directions for novel therapeutic opportunities, including evidence-based strategic repurposing of currently used familiar/approved medications Language eng DOI 10.3390/biom11091394 Field of Research 0601 Biochemistry and Cell Biology HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30156375 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Link to full-text (open access)   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Fri, 01 Oct 2021, 08:02:15 EST Sun, 03 Oct 2021, 19:27:02 EST Sat, 23 Oct 2021, 01:30:16 EST Fri, 12 Nov 2021, 05:12:41 EST Tue, 14 Dec 2021, 13:53:44 EST Tue, 14 Dec 2021, 15:32:30 EST Tue, 14 Dec 2021, 15:35:55 EST Filtered Full Citation counts:   Cited 1 times in TR Web of Science Cited 1 times in Scopus Search Google Scholar Access Statistics: 38 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Fri, 01 Oct 2021, 08:02:15 EST