A biomarker and endophenotype for anorexia nervosa? Phillipou, A, Rossell, SL, Gurvich, C, Castle, DJ, Meyer, D and Abel, Larry 2021, A biomarker and endophenotype for anorexia nervosa?, Australian and New Zealand Journal of Psychiatry, pp. 1-9, doi: 10.1177/00048674211047189. Attached Files Name Description MIMEType Size Downloads Title A biomarker and endophenotype for anorexia nervosa? Author(s) Phillipou, A Rossell, SL Gurvich, C Castle, DJ Meyer, D Abel, Larry orcid.org/0000-0002-2393-0644 Journal name Australian and New Zealand Journal of Psychiatry Article ID 00048674211047189 Start page 1 End page 9 Total pages 9 Publisher Sage Place of publication London, Eng. Publication date 2021-09-18 ISSN 0004-8674 1440-1614 Keyword(s) Anorexia nervosa ANXIETY DISORDERS biomarker BODY-IMAGE CELLS endophenotype eye movements Life Sciences & Biomedicine MORTALITY Psychiatry RECOVERY SACCADIC EYE-MOVEMENTS Science & Technology square wave jerks SQUARE-WAVE JERKS SUPERIOR COLLICULUS TASK Summary Objective: Recent research has suggested that a type of atypical eye movement, called square wave jerks, together with anxiety, may distinguish individuals with anorexia nervosa from those without anorexia nervosa and may represent a biomarker and endophenotype for the illness. The aim of this study was to identify the presence of this proposed marker in individuals currently with anorexia nervosa relative to healthy controls, and to identify the state independence and heritability of this putative marker by exploring whether it also exists in individuals who are weight-restored from anorexia nervosa and first-degree relatives (i.e. sisters of people with anorexia nervosa). Methods: Data from 80 female participants (20/group: current anorexia nervosa, weight-restored from anorexia nervosa, sisters of people with anorexia nervosa and healthy controls) were analysed. Square wave jerk rate was acquired during a fixation task, and anxiety was measured with the State Trait Anxiety Inventory. Results: Current anorexia nervosa, weight-restored from anorexia nervosa and sisters of people with anorexia nervosa groups made significantly more square wave jerks than healthy controls, but did not differ from one another. Square wave jerk rate and anxiety were found to discriminate groups with exceptionally high accuracy (current anorexia nervosa vs healthy control = 92.5%; weight-restored from anorexia nervosa vs healthy control = 77.5%; sisters of people with anorexia nervosa vs healthy control = 77.5%; p < .001). Conclusion: The combination of square wave jerk rate and anxiety was found to be a promising two-element marker for anorexia nervosa, and has the potential to be used as a biomarker or endophenotype to identify people at risk of anorexia nervosa and inform future treatments. Language eng DOI 10.1177/00048674211047189 Field of Research 11 Medical and Health Sciences 17 Psychology and Cognitive Sciences HERDC Research category C1 Refereed article in a scholarly journal Persistent URL http://hdl.handle.net/10536/DRO/DU:30156491 Document type: Journal Article Collections: Faculty of Health School of Medicine Related Links Link Description Connect to published version Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Wed, 06 Oct 2021, 07:13:05 EST Wed, 06 Oct 2021, 15:04:16 EST Wed, 06 Oct 2021, 15:06:06 EST Tue, 18 Jan 2022, 16:35:05 EST Wed, 23 Feb 2022, 10:44:10 EST Wed, 23 Feb 2022, 11:09:23 EST Wed, 23 Feb 2022, 11:27:44 EST Wed, 23 Feb 2022, 11:28:43 EST Wed, 23 Feb 2022, 15:33:15 EST Wed, 23 Feb 2022, 15:36:52 EST Wed, 30 Mar 2022, 13:08:18 EST Filtered Full Citation counts:   Cited 1 times in TR Web of Science Cited 1 times in Scopus Search Google Scholar Access Statistics: 32 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Wed, 06 Oct 2021, 07:13:05 EST