A proteomic view of cellular and molecular effects of cannabis Abyadeh, M, Gupta, V, Paulo, JA, Gupta, Veer, Chitranshi, N, Godinez, A, Saks, D, Hasan, M, Amirkhani, A, McKay, M, Salekdeh, GH, Haynes, PA, Graham, SL and Mirzaei, M 2021, A proteomic view of cellular and molecular effects of cannabis, Biomolecules, vol. 11, no. 10, pp. 1-17, doi: 10.3390/biom11101411. Title A proteomic view of cellular and molecular effects of cannabis Author(s) Abyadeh, M Gupta, V Paulo, JA Gupta, Veer orcid.org/0000-0003-4989-0764 Chitranshi, N Godinez, A Saks, D Hasan, M Amirkhani, A McKay, M Salekdeh, GH Haynes, PA Graham, SL Mirzaei, M Journal name Biomolecules Volume number 11 Issue number 10 Article ID 1411 Start page 1 End page 17 Total pages 17 Publisher MDPI Place of publication Basel, Switzerland Publication date 2021 ISSN 2218-273X 2218-273X Keyword(s) ADOLESCENT Biochemistry & Molecular Biology BRAIN cannabidiol cannabinoids cannabis CELLS DELTA(9)-TETRAHYDROCANNABINOL ENDOCANNABINOID SYSTEM EXPOSURE Life Sciences & Biomedicine marijuana MOUSE MODEL MULTIPLE-SCLEROSIS PROTEIN EXPRESSION proteomics Science & Technology tetrahydrocannabinol THC Summary Cannabis (Cannabis sativa), popularly known as marijuana, is the most commonly used psychoactive substance and is considered illicit in most countries worldwide. However, a growing body of research has provided evidence of the therapeutic properties of chemical components of cannabis known as cannabinoids against several diseases including Alzheimer’s disease (AD), multiple sclerosis (MS), Parkinson’s disease, schizophrenia and glaucoma; these have prompted changes in medicinal cannabis legislation. The relaxation of legal restrictions and increased socio-cultural acceptance has led to its increase in both medicinal and recreational usage. Several biochemically active components of cannabis have a range of effects on the biological system. There is an urgent need for more research to better understand the molecular and biochemical effects of cannabis at a cellular level, to understand fully its implications as a pharmaceutical drug. Proteomics technology is an efficient tool to rigorously elucidate the mechanistic effects of cannabis on the human body in a cell and tissue-specific manner, drawing conclusions associated with its toxicity as well as therapeutic benefits, safety and efficacy profiles. This review provides a comprehensive overview of both in vitro and in vivo proteomic studies involving the cellular and molecular effects of cannabis and cannabis-derived compounds Language eng DOI 10.3390/biom11101411 Indigenous content off Field of Research 0601 Biochemistry and Cell Biology HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30156493 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Connect to full text (open access) Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Wed, 06 Oct 2021, 07:13:39 EST Wed, 06 Oct 2021, 15:04:18 EST Wed, 06 Oct 2021, 15:06:09 EST Fri, 12 Nov 2021, 05:07:14 EST Sat, 20 Nov 2021, 01:31:19 EST Wed, 15 Dec 2021, 10:11:22 EST Wed, 15 Dec 2021, 15:32:12 EST Wed, 15 Dec 2021, 15:37:51 EST Mon, 17 Jan 2022, 13:24:33 EST Filtered Full Citation counts:   Cited 1 times in TR Web of Science Cited 1 times in Scopus Search Google Scholar Access Statistics: 55 Abstract Views  -  Detailed Statistics Created: Wed, 06 Oct 2021, 07:13:39 EST