SOCS Proteins in Immunity, Inflammatory Diseases, and Immune-Related Cancer Sobah, ML, Liongue, Clifford and Ward, Alister 2021, SOCS Proteins in Immunity, Inflammatory Diseases, and Immune-Related Cancer, Frontiers in Medicine, vol. 8, pp. 1-23, doi: 10.3389/fmed.2021.727987. Attached Files Name Description MIMEType Size Downloads Title SOCS Proteins in Immunity, Inflammatory Diseases, and Immune-Related Cancer Author(s) Sobah, ML Liongue, Clifford orcid.org/0000-0002-1646-4905 Ward, Alister orcid.org/0000-0001-7945-7975 Journal name Frontiers in Medicine Volume number 8 Article ID 727987 Start page 1 End page 23 Total pages 23 Publisher Frontiers Place of publication Lausanne, Switzerland Publication date 2021-09 ISSN 2296-858X 2296-858X Keyword(s) cancer CHRONIC MYELOID-LEUKEMIA cytokine CYTOKINE SIGNALING 3 DENDRITIC CELLS General & Internal Medicine IFN-GAMMA immunity INDUCIBLE SH2-CONTAINING PROTEIN inflammation Life Sciences & Biomedicine Medicine, General & Internal MESSENGER-RNA MICE LACKING SUPPRESSOR PHYSIOLOGICAL NEGATIVE REGULATOR REGULATORY T-CELLS Science & Technology SH2 DOMAIN SOCS Summary Cytokine signaling represents one of the cornerstones of the immune system, mediating the complex responses required to facilitate appropriate immune cell development and function that supports robust immunity. It is crucial that these signals be tightly regulated, with dysregulation underpinning immune defects, including excessive inflammation, as well as contributing to various immune-related malignancies. A specialized family of proteins called suppressors of cytokine signaling (SOCS) participate in negative feedback regulation of cytokine signaling, ensuring it is appropriately restrained. The eight SOCS proteins identified regulate cytokine and other signaling pathways in unique ways. SOCS1–3 and CISH are most closely involved in the regulation of immune-related signaling, influencing processes such polarization of lymphocytes and the activation of myeloid cells by controlling signaling downstream of essential cytokines such as IL-4, IL-6, and IFN-γ. SOCS protein perturbation disrupts these processes resulting in the development of inflammatory and autoimmune conditions as well as malignancies. As a consequence, SOCS proteins are garnering increased interest as a unique avenue to treat these disorders Language eng DOI 10.3389/fmed.2021.727987 HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30156799 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Link to full-text (open access)   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Sun, 10 Oct 2021, 13:28:30 EST Mon, 11 Oct 2021, 15:00:13 EST Mon, 11 Oct 2021, 15:04:09 EST Sat, 16 Oct 2021, 01:50:04 EST Fri, 12 Nov 2021, 05:08:03 EST Wed, 15 Dec 2021, 12:28:37 EST Wed, 15 Dec 2021, 15:32:22 EST Wed, 15 Dec 2021, 15:38:47 EST Filtered Full Citation counts:   Cited 5 times in TR Web of Science Cited 4 times in Scopus Search Google Scholar Access Statistics: 52 Abstract Views, 1 File Downloads  -  Detailed Statistics Created: Sun, 10 Oct 2021, 13:28:30 EST