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Reporter-gene assays for monoclonal antibodies

Ray, Kriti Bimalendu 2019, Reporter-gene assays for monoclonal antibodies, Ph.D. thesis, School of Life and Environmental Sciences, Deakin University.

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Title Reporter-gene assays for monoclonal antibodies
Author Ray, Kriti Bimalendu
Institution Deakin University
School School of Life and Environmental Sciences
Faculty Faculty of Science, Engineering and Built Environment
Degree type Research doctorate
Degree name Ph.D.
Thesis advisor Donald, John
Ujvari, BeataORCID iD for Ujvari, Beata orcid.org/0000-0003-2391-2988
Date submitted 2019-02
Summary There is a need to develop rapid, sensitive and cost-effective potency assays to test monoclonal antibodies (MAbs). This study investigated the use of reporter-gene assays (RGAs) as potency assays, to test anti-IL-6/IL6R and anti-EGF/EGFR MAbs, using destabilized EGFP and luciferase as reporter genes.
Language eng
Indigenous content off
Field of Research 111204 Cancer Therapy (excl Chemotherapy and Radiation Therapy)
060111 Signal Transduction
060113 Synthetic Biology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
Description of original 366 p.
Copyright notice ©The author
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30156982

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Created: Thu, 14 Oct 2021, 15:04:16 EST by Bec Miller

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.