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Carotid artery intima-media thickness, distensibility and elasticity: Population epidemiology and concordance in Australian children aged 11-12 years old and their parents

Liu, RS, Dunn, S, Grobler, AC, Lange, K, Becker, Denise, Goldsmith, G, Carlin, JB, Juonala, M, Wake, M and Burgner, DP 2019, Carotid artery intima-media thickness, distensibility and elasticity: Population epidemiology and concordance in Australian children aged 11-12 years old and their parents, BMJ Open, vol. 9, pp. 23-33, doi: 10.1136/bmjopen-2017-020264.

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Title Carotid artery intima-media thickness, distensibility and elasticity: Population epidemiology and concordance in Australian children aged 11-12 years old and their parents
Author(s) Liu, RS
Dunn, S
Grobler, AC
Lange, K
Becker, Denise
Goldsmith, G
Carlin, JB
Juonala, M
Wake, M
Burgner, DP
Journal name BMJ Open
Volume number 9
Start page 23
End page 33
Total pages 11
Publisher BMJ
Place of publication London, Eng.
Publication date 2019
ISSN 2044-6055
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
intima-media thickness
distensibility
reference values
children
inheritance patterns
epidemiological studies
RISK-FACTORS
MYOCARDIAL-INFARCTION
CARDIOVASCULAR RISK
FAMILIAL HYPERCHOLESTEROLEMIA
PHYSICAL HEALTH
ATHEROSCLEROSIS
ULTRASOUND
STROKE
HERITABILITY
ADOLESCENTS
Summary Objectives To describe a well-established marker of cardiovascular risk, carotid intima-media thickness (IMT) and related measures (artery distensibility and elasticity) in children aged 11-12 years old and mid-life adults, and examine associations within parent-child dyads. Design Cross-sectional study (Child Health CheckPoint), nested within a prospective cohort study, the Longitudinal Study of Australian Children (LSAC). Setting Assessment centres in seven Australian major cities and eight selected regional towns, February 2015 to March 2016. Participants Of all participating CheckPoint families (n=1874), 1489 children (50.0% girls) and 1476 parents (86.8% mothers) with carotid IMT data were included. Survey weights and methods were applied to account for LSAC's complex sample design and clustering within postcodes and strata. Outcome measures Ultrasound of the right carotid artery was performed using standardised protocols. Primary outcomes were mean and maximum far-wall carotid IMT, quantified using semiautomated edge detection software. Secondary outcomes were carotid artery distensibility and elasticity. Pearson's correlation coefficients and multivariable linear regression models were used to assess parent-child concordance. Random effects modelling on a subset of ultrasounds (with repeated measurements) was used to assess reliability of the child carotid IMT measure. Results The average mean and maximum child carotid IMT were 0.50 mm (SD 0.06) and 0.58 mm (SD 0.05), respectively. In adults, average mean and maximum carotid IMT were 0.57 mm (SD 0.07) and 0.66 mm (SD 0.10), respectively. Mother-child correlations for mean and maximum carotid IMT were 0.12 (95% CI 0.05 to 0.23) and 0.10 (95% CI 0.03 to 0.21), respectively. For carotid artery distensibility and elasticity, mother-child correlations were 0.19 (95% CI 0.10 to 0.25) and 0.11 (95% CI 0.02 to 0.18), respectively. There was no strong evidence of father-child correlation in any measure. Conclusions We provide Australian values for carotid vascular measures and report a modest mother-child concordance. Both genetic and environmental exposures are likely to contribute to carotid IMT
Language eng
DOI 10.1136/bmjopen-2017-020264
Field of Research 1103 Clinical Sciences
1117 Public Health and Health Services
1199 Other Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30158143

Document type: Journal Article
Collections: Faculty of Health
PVC's Office - Health
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.