Frailty confers high mortality risk across different populations: Evidence from an overview of systematic reviews and meta-analyses Ofori-Asenso, R, Chin, KL, Sahle, Berhe, Mazidi, M, Zullo, AR and Liew, D 2020, Frailty confers high mortality risk across different populations: Evidence from an overview of systematic reviews and meta-analyses, Geriatrics, vol. 5, no. 1, pp. 1-14, doi: 10.3390/GERIATRICS5010017. Attached Files Name Description MIMEType Size Downloads Title Frailty confers high mortality risk across different populations: Evidence from an overview of systematic reviews and meta-analyses Author(s) Ofori-Asenso, R Chin, KL Sahle, Berhe Mazidi, M Zullo, AR Liew, D Journal name Geriatrics Volume number 5 Issue number 1 Article ID 17 Start page 1 End page 14 Total pages 14 Publisher MDPI Place of publication Basel, Switzerland Publication date 2020 ISSN 2308-3417 2308-3417 Keyword(s) evidence synthesis FALLS frailty Geriatrics & Gerontology IMPLANTATION Life Sciences & Biomedicine meta-analyses MORBIDITY mortality OUTCOMES PEOPLE PREDICTOR PREVALENCE Science & Technology SEX-DIFFERENCES umbrella review Summary We performed an overview of systematic reviews and meta-analyses to summarize available data regarding the association between frailty and all-cause mortality. Medline, Embase, CINAHL, Web of Science, PsycINFO, and AMED (Allied and Complementary Medicine) databases were searched until February 2020 for meta-analyses examining the association between frailty and all-cause mortality. The AMSTAR2 checklist was used to evaluate methodological quality. Frailty exposure and the risk of all-cause mortality (hazard ratio [HR] or relative risk [RR]) were displayed in forest plots. We included 25 meta-analyses that pooled data from between 3 and 20 studies. The number of participants included in these meta-analyses ranged between <2000 and >500,000. Overall, 56%, 32%, and 12% of studies were rated as of moderate, low, and critically low quality, respectively. Frailty was associated with increased risk of all-cause mortality in 24/24 studies where the HR/RRs ranged from 1.35 [95% confidence interval (CI) 1.05–1.74] (patients with diabetes) to 7.95 [95% CI 4.88–12.96] (hospitalized patients). The median HR/RR across different meta-analyses was 1.98 (interquartile range 1.65–2.67). Pre-frailty was associated with a significantly increased risk of all-cause mortality in 7/7 studies with the HR/RR ranging from 1.09 to 3.65 (median 1.51, IQR 1.38–1.73). These data suggest that interventions to prevent frailty and pre-frailty are needed Language eng DOI 10.3390/GERIATRICS5010017 Field of Research 1103 Clinical Sciences 1117 Public Health and Health Services HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30158879 Document type: Journal Article Collections: Faculty of Health Open Access Collection Institute for Health Transformation Related Links Link Description Link to full-text (open access)   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 22 Nov 2021, 07:14:49 EST Mon, 22 Nov 2021, 15:14:14 EST Mon, 22 Nov 2021, 15:20:59 EST Fri, 26 Nov 2021, 15:13:40 EST Sat, 04 Dec 2021, 01:32:37 EST Sat, 04 Dec 2021, 01:48:19 EST Fri, 14 Jan 2022, 14:20:34 EST Fri, 14 Jan 2022, 15:27:18 EST Fri, 14 Jan 2022, 15:32:17 EST Filtered Full Citation counts:   Cited 3 times in TR Web of Science Cited 3 times in Scopus Search Google Scholar Access Statistics: 26 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Mon, 22 Nov 2021, 07:14:49 EST